Evidence map›Paper›PMID 40291747›Full record

ArticlebioRxiv : the preprint server for biology2025

High-content microscopy and machine learning characterize a cell morphology signature of

Jenna Tomkinson, Cameron Mattson, Michelle Mattson-Hoss, Herb Sarnoff, Stephanie J Bouley, James A Walker, Gregory P Way

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jenna TomkinsonDepartment of Biomedical Informatics, University of Colorado School of Medicine.ORCID 0000-0003-2676-5813
Cameron MattsonDepartment of Biomedical Informatics, University of Colorado School of Medicine.ORCID 0009-0008-4969-779X
Michelle Mattson-HossInfixion Bioscience, Inc., San Diego, CA.
Herb SarnoffInfixion Bioscience, Inc., San Diego, CA.ORCID 0000-0002-3219-3113
Stephanie J BouleyCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0785-0860
James A WalkerCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5585-698X
Gregory P WayDepartment of Biomedical Informatics, University of Colorado School of Medicine.ORCID 0000-0002-0503-9348

Funding

Partners Healthcare Training Program in Precision and Genomic MedicineT32HG010464 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDI L REHM, JORDAN W SMOLLER · 2019 to 2026
$3.1M
NHGRI NIH HHS T32 HG010464
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is a multi-system, autosomal dominant genetic disorder driven by the systemic loss of the NF1 protein neurofibromin. Loss of neurofibromin in Schwann cells is particularly detrimental, as the acquisition of a 'second-hit' (e.g., complete loss of

Identifiers

PMID40291747
PMCPMC12026412

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.