Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Yeara JoDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-1340-1968
Trever T Greene *Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Carolina Chiale *Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-8432-2802
Kai Zhang *Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.
Ziyan FangDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Simone DallariDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Nuha MarookiDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0003-2335-6889
Wei WangDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0003-4377-5060
Elina I ZunigaDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-8699-1623
Funding
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Single-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8M
Inhibitory Pathways Underlying Viral Persistence In VivoR01AI081923 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elina I Zuniga · 2009 to 2026
$6.6M
Positive Immune-regulators During Chronic Viral InfectionsR01AI113923 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2015 to 2024
$5.1M
Molecular Mechanisms Underlying Dendritic Cell Adaptations During Chronic InfectionR01AI145314 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2020 to 2024
$2.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI081923HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI113923HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI132122HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI145314NIAID NIH HHS P01 AI132122NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI081923NIAID NIH HHS R01 AI113923NIAID NIH HHS R01 AI145314San Diego Center for Precision Immunotherapy Learning from Viruses How to Restore Type 1 Interferons in Cancer
6 · The paper itself
Abstract
Plasmacytoid Dendritic cells (pDCs) are the most potent producers of interferons, which are critical antiviral cytokines. pDC development is, however, compromised following a viral infection, and this phenomenon, as well as its relationship to conventional (c)DC development is still incompletely understood. By using lymphocytic choriomeningitis virus (LCMV) infection in mice as a model system, we observed that DC progenitors skewed away from pDC and toward cDC development during in vivo viral infection. Subsequent characterization of the transcriptional and epigenetic landscape of fms-like tyrosine kinase 3
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation. · full record | Socratic