Evidence map›Paper›PMID 40295482›Full record

ArticleNature communications2025

Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases.

Junfeng Chen, Kousuke Okimura, Liang Ren, Yusuke Nakane, Tomoya Nakayama, Yang Chen, Kai Fukawa, Soutarou Sugiyama, Takayoshi Natsume, Naoko Suda-Hashimoto and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Junfeng Chen *Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0000-0001-6155-411X
Kousuke Okimura *Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Liang Ren *Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Yusuke NakaneInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Tomoya NakayamaLaboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0000-0003-4175-3167
Yang ChenInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Kai FukawaInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0009-0001-6230-8903
Soutarou SugiyamaCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.
Takayoshi NatsumeCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.ORCID http://orcid.org/0009-0002-3089-014X
Naoko Suda-HashimotoCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.
Mayumi MorimotoCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.
Takako Miyabe-NishiwakiCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.
Takao OishiCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.ORCID http://orcid.org/0000-0003-1067-3746
Yuma KatadaInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0000-0002-5276-1691
Manhui ZhangInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Kohei KobayashiInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Shoko MatsumotoInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Taiki YamaguchiInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.
Ying-Jey GuhInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0000-0003-1148-8315
Issey TakahashiInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0009-0007-8397-8627
Taeko Nishiwaki-OhkawaInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan.ORCID http://orcid.org/0000-0003-1324-6651
Daiki X SatoInstitute for Advanced Academic Research, Chiba University, Chiba, Chiba, 263-8522, Japan.ORCID http://orcid.org/0000-0002-9527-8253
Yoshiharu MurataSeien Clinic, Hamamatsu, Shizuoka, 434-0026, Japan.
Kenta SumiyamaLaboratory of Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research (BDR), Suita, Osaka, 565-0871, Japan.ORCID http://orcid.org/0000-0001-8785-5439
Atsushi J NaganoFaculty of Agriculture, Ryukoku University, Otsu, Shiga, 520-2194, Japan.ORCID http://orcid.org/0000-0001-7891-5049
Hiroo ImaiCenter for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, 484-8506, Japan.
Takashi YoshimuraInstitute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Nagoya, Aichi, 464-8601, Japan. takashiy@agr.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0001-7018-9652

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19H05643MEXT | Japan Society for the Promotion of Science (JSPS) 24H00058MEXT | Japan Society for the Promotion of Science (JSPS) 24H02303MEXT | Japan Society for the Promotion of Science (JSPS) 26000013
6 · The paper itself

Abstract

The metabolic, immune, and endocrine systems show profound seasonal changes in animals, including humans. In addition, morbidity from cardiovascular and psychiatric diseases is more severe and mortality rate is higher in winter. However, their molecular mechanisms remain unknown. Here we report the seasonal transcriptome of 80 tissues collected over 1 year from male and female rhesus macaques kept in a semi-natural outdoor environment. We find seasonal changes in plasma metabolites and hormones. Transcriptome analysis identifies sex differences in seasonally oscillating genes (SOGs) in all tissues studied, and we generate the web database 'Non-Human Primate Seasonal Transcriptome Atlas (NHPSTA).' Transcriptional regulatory network analysis, siRNA knockdown, and mutant mouse analyses reveal regulation of SOGs by GA-binding protein (GABP). We also demonstrate seasonal oscillations in the expression of disease risk factor genes and drug interacting genes. NHPSTA provides a molecular resource for seasonally regulated physiology and targets for therapeutic interventions for seasonally regulated diseases.

Indexed as

Macaca mulattaSeasonsTranscriptomeAnimalsFemaleGene Expression ProfilingGene Regulatory NetworksMaleMice

Identifiers

PMID40295482
PMCPMC12037758

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.