ArticleScientific reports2025
The effect of blue and green light on human umbilical cord mesenchymal stem cells for promoting proliferation and wound healing.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Photobiomodulation-reprogrammed extracellular vesicles deliveredActa pharmaceutica Sinica. B · 2026Article
- Review
- Photobiomodulation stimulates mitochondrial function and cell proliferation in meniscus-derived stem cells (MeSCs) via activation of TRPV1 channel.Scientific reports · 2025Article
- FTIR spectroscopic characterization reveals short-term macromolecular responses to photobiomodulation in mesenchymal stem cells.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Photobiomodulation (PBM) has been widely utilized in regenerative medicine, including dermatology, dentistry, and neurology. However, the optimal energy density of PBM for human umbilical cord mesenchymal stem cells (hUC-MSCs) remains underexplored, hindering its development and potential clinical application. This study aims to identify the optimal wavelength and irradiation fluence for promoting the proliferation of hUC-MSCs by comparing the effects of different wavelengths and irradiation fluences. Our results show that green light enhances the anti-inflammatory properties of hUC-MSCs, with the 76s being the most effective in inhibiting IL-6 and GM-CSF. Blue light with 38 s is more effective in promoting angiogenesis, significantly increasing the mRNA and protein secretion of VEGF, HGF, and FGF2 compared to the non-irradiated group. The peak secretion times varied, with VEGF and FGF2 peaking at 72 h and HGF at 24 h. RNA-Seq confirms the significant roles of blue and green light in inhibiting epithelial-mesenchymal transition and inflammation. In vitro co-culture models and conditioned media experiments validate these anti-inflammatory effects. These findings have important implications for accelerating the clinical application of stem cell therapies and provide new references for PBM use in hUC-MSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.