Evidence map›Paper›PMID 40296124›Full record

ArticleRespiratory research2025

Mechanical stress facilitates calcium influx and growth of alveolar epithelial cells via activation of the BDKRB1/Ca

Ying Zhang, Qing-Dong Zhang, Quan Li, Zhi-Yue Shi, Cheng Pan, Rong-Shuang Yan, De-Rui Fei, Shi-Xin Xu, Yang Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying Zhang *Department of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China. zhangying6@kmmu.edu.cn.
Qing-Dong Zhang *Department of Surgery, Yuxi Hospital Affiliated to Kunming University of Science and Technology, The Second People's Hospital of Yuxi, No.4 Xingyun Road, Yuxi, Yunnan, China.
Quan LiDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
Zhi-Yue ShiDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
Cheng PanDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
Rong-Shuang YanDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
De-Rui FeiDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
Shi-Xin XuDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.
Yang LuoDepartment of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, No.374, Dianmian Avenue, Kunming, Yunnan, China.

Funding

"Famous Doctor" Special Fund of Yunnan Revitalization Talent Support Program 2022-XDYC-MY-2022-0026Key Research and Development Program of Yunnan Provincial Science and Technology Depart-ment 202403AC100008National Natural Science Foundation of China 82060414Special and Joint Program of Yunnan Provincial Science and Technology Department & Kunming Medical University 202101AY070001-150
6 · The paper itself

Abstract

backgroundMechanical stress and calcium metabolism are associated with lung development and various pulmonary diseases. Our previous research demonstrated that BDKRB1/Ca

methodsFlow cytometry, CCK-8, and EDU staining assay were employed to assess the cycle, calcium influx, activity, and proliferation in RLE-6TN cells subjected to mechanical stresses of varying amplitudes (5%, 10% and 15%). RT-qPCR and western blotting assay were performed to evaluate the effects of mechanical stress on BDKRB1/Ca

resultsMechanical stress at 10% amplitudes effectively enhanced the viability, EDU positive ratio, S-phase percentage, and Ca

conclusionAppropriate levels of mechanical stress contribute to the growth and calcium influx of alveolar epithelial cells by modulating BDKRB1/Ca

Indexed as

Alveolar Epithelial CellsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCell ProliferationMAP Kinase Kinase 1MAP Kinase Signaling SystemStress, MechanicalAnimalsCell LineHumansRatsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2MAP Kinase Kinase 1Alveolar epithelial cellsBradykinin receptor B1CalciumGrowthMechanical stress

Identifiers

PMID40296124
PMCPMC12038983

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.