Evidence map›Paper›PMID 40296131›Full record

ArticleEuropean journal of medical research2025

Characterization of T cells in the progression of dry eye disease using single-cell RNA sequencing in mice.

Zhizhi Zhang, Liwei Zhang, Baihua Chen

Abstract read
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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhizhi ZhangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Liwei ZhangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Baihua ChenDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. chenbaihua2017@csu.edu.cn.

Funding

Hunan Natural Science Foundation 2021JJ30925Hunan Provincial Health Commission Foundation B202307026146Hunan Provincial Health High-Level Talent Scientific Research Project R2023025The National Natural Science Foundation of China 81870678The National Natural Science Foundation of China 82171030
6 · The paper itself

Abstract

backgroundIncreasing evidence indicated that T cells have significant effects in dry eye disease (DED). However, the regulatory role of T cells in DED remains unclear.

methodsIn this study, we examined immune responses throughout the progression in murine DED model. Using cytometry by time-of-flight (CyTOF) and single-cell RNA sequencing (scRNA-seq), we observed dynamic alterations in the proportions of immune cell landscape. Pseudotime trajectory and cell-cell communication analyses further illustrated T-cell differentiation and interaction networks.

resultsCD4

conclusionsOur results clarify the dynamics of the adaptive immune response in DED and indicate that targeting T cells may serve as a promising immune-modulatory approach in the treatment of DED model.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDry Eye SyndromesT-LymphocytesAnimalsDisease Models, AnimalDisease ProgressionMiceMice, Inbred C57BLSequence Analysis, RNASingle-Cell AnalysisDry eye disease (DED)Immune modulationImmune responseScRNA-seqT cellTherapy

Identifiers

PMID40296131
PMCPMC12036131

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.