Evidence map›Paper›PMID 40296476›Full record

ArticleJournal of the International Neuropsychological Society : JINS2025

Independent and combined adverse effects of neurocognitive impairment and depression on everyday functioning and quality of life in people with HIV.

Crystal X Wang, Victoria O Chentsova, Maximo R Prescott, Anya Umlauf, David J Moore, Ronald J Ellis, Mariana Cherner, Murray B Stein, Scott L Letendre, Robert K Heaton and 1 more

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Article in Journal of the International Neuropsychological Society : JINS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Crystal X WangDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.ORCID https://orcid.org/0000-0002-0525-809X
Victoria O ChentsovaSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Maximo R PrescottSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Anya UmlaufDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.
David J MooreDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.
Ronald J EllisDepartment of Neurosciences, University of California, San Diego, CA, USA.
Mariana ChernerDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.
Murray B SteinDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.
Scott L LetendreDepartment of Infectious Disease, University of California, San Diego, CA, USA.
Robert K HeatonDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.
Jennifer E IudicelloDepartment of Psychiatry, University of California, San DiegoHIV Neurobehavioral Research Program, San Diego, CA, USA.ORCID https://orcid.org/0000-0003-2854-7684

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FLORIN VAIDA · 2001 to 2026
$50.4M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Identification of Biomarkers of CNS injury and resilience related to HIV-1 and MethamphetamineR01DA047879 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IUDICELLO, JENNIFER E, LETENDRE, SCOTT L · 2018 to 2022
$3.7M
NIDA NIH HHS R01 DA047879NIDA NIH HHS T32 DA031098NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

objectiveDespite advances in antiretroviral treatment (ART), human immunodeficiency virus (HIV) can detrimentally affect everyday functioning. Neurocognitive impairment (NCI) and current depression are common in people with HIV (PWH) and can contribute to poor functional outcomes, but potential synergies between the two conditions are less understood. Thus, the present study aimed to compare the independent and combined effects of NCI and depression on everyday functioning in PWH. We predicted worse functional outcomes with comorbid NCI and depression than either condition alone.

methodsPWH enrolled at the UCSD HIV Neurobehavioral Research Program were assessed for neuropsychological performance, depression severity (≤minimal, mild, moderate, or severe; Beck Depression Inventory-II), and self-reported everyday functioning.

resultsParticipants were 1,973 PWH (79% male; 66% racial/ethnic minority; Age:

conclusionsConsistent with prior literature, NCI and depression had independent effects on everyday functioning in PWH. There was also evidence for combined effects of NCI and depression, such that their comorbidity had a greater impact on functioning than either alone. Our results have implications for informing future interventions to target common, comorbid NCI and depressed mood in PWH and thus reduce HIV-related health disparities.

Indexed as

depressive symptomseveryday functioningHIV-associated neurocognitive impairmentHIV comorbiditiesmajor depressive disorderquality of life

Identifiers

PMID40296476
PMCPMC12427598

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.