ReviewDrug design, development and therapy2025
Therapeutic Challenges of Diabetes Mellitus-Related Erectile Dysfunction and The Potential Therapeutic Role of Medicinal Plants: A Narrative Review.
Review in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Efficacy of Lingji Formula in the Treatment of Male Infertility in Obese Men: Study Protocol for a Randomized Controlled Trial.International journal of general medicine · 2026Article
- Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets.International journal of biological sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erectile dysfunction (ED) is a common male sexual dysfunction and can be induced by diabetes mellitus (DM). Diabetes mellitus-induced erectile dysfunction (DMED) affects various aspects of the patient's quality of life, mental well-being, and relationship dynamics. Given the increasing incidence of DM worldwide, the incidence of DMED is expected to increase accordingly. There are more challenges to treat DMED compared to non-DMED. The efficacy of oral phosphodiesterase-5 inhibitors is often ineffective in DMED and there is a need to search for effective drugs. Medicinal plants such as Eucommia ulmoides Oliv. Leaf, Cordycep militaris have been used in treating DMED in some experiments. And some ingredients from the medicinal plants such as Icariside II, Panax notoginseng Saponins have also shown to be beneficial in improving erectile function in animal models of DMED. These medicinal plants and ingredients may act by regulating hormone levels, ameliorating oxidative damage, and promoting NO/cGMP. We summarize the challenges in treating DMED due to related complicated pathogenesis and limited therapeutic options, while particularly highlight the role of the medicinal plants and their ingredients in DMED.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.