ArticleFrontiers in nutrition2025
Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007-2016.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of Lycopene Intake on Mental Health: A Systematic Review of Randomized Controlled Trials (RCTs).Nutrients · 2025Pooled it
- Lycopene attenuates dexamethasone induced depression like behavior and immunological dysfunction via restoration of neuro-immune-metabolic homeostasis in rats.Scientific reports · 2026Article
- Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits.International journal of molecular sciences · 2026Review
- The Association Between Dietary Fiber Intake and Depression Among US Adults: A Cross-Sectional Study Based on NHANES Data From 2005 to 2020.Food science & nutrition · 2025Article
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2 authors.
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Abstract
Introduction: Although previous researches have suggested that certain dietary nutrients, such as carotenoids, have an effect on depression, epidemiological evidence on the relationship between lycopene and depression remains limited. This study aimed to investigate the association between dietary lycopene intake and depression risk in American adults. Methods: Data from 18,664 participants in the National Health and Nutrition Examination Survey (NHANES, 2007-2016) were analyzed, with depression defined by a nine-item Patient Health Questionnaire (PHQ-9) score ≥ 10. Dietary lycopene intake was estimated from the mean of two 24-h dietary recalls. Binary logistic regression and restricted cubic spline (RCS) models were employed to assess the relationship. Results: Depression prevalence was 8.98%, and adjusted analyses indicated that higher dietary lycopene intake was significantly associated with a reduced depression risk compared to the lowest quartile (ORs for the second, third, and fourth quartiles: 0.851 [95% CI, 0.737-0.982], 0.829 [95% CI, 0.716-0.960], and 0.807 [95% CI, 0.695-0.938], respectively). Additionally, a U-shaped relationship was observed, with a reduction in depression risk associated with dietary lycopene intake ranging from 0 to 10,072 μg/d ( Discussion: This study suggested that higher dietary lycopene intake may confer a protective effect against depression in American adults.
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