Evidence map›Paper›PMID 40297439›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Association between epigenetic aging acceleration and amyloid biomarkers in bipolar disorder.

Gabriel R Fries, Steven De La Garza, Ning O Zhao, Andres W Bass, Camila N C Lima, Nobuhide Kobori, Tatiana Barichello, Gustavo Turecki, Paul E Schulz, Breno S Diniz and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Gabriel R FriesTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.ORCID 0000-0002-5468-2612
Steven De La GarzaTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.
Ning O ZhaoTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.
Andres W BassTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.
Camila N C LimaTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.
Nobuhide KoboriDepartment of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.
Tatiana BarichelloTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.ORCID 0000-0001-7776-8454
Gustavo TureckiDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-4075-2736
Paul E SchulzDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Neurocognitive Disorders Center, McGovern Medical School, The University of Texas Health Science Center at Houston Neurosciences, Houston, Texas, USA.
Breno S DinizUConn Center on Aging & Department of Psychiatry, UConn School of Medicine, University of Connecticut Health Center, USA.ORCID 0000-0003-0653-1905
Jair C SoaresTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, Houston, Texas, USA.ORCID 0000-0002-5466-5628

Funding

Infection-driven mechanisms associated with Alzheimer's disease pathologyR01AG072491 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BARICHELLO, TATIANA, MORALES, RODRIGO · 2024 to 2025
$1.2M
Deciphering the role of neuronal and peripheral DNA methylation in suicide and bipolar disorderK01MH121580 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FRIES, GABRIEL RODRIGO · 2020 to 2023
$699k
NIA NIH HHS R01 AG072491NIMH NIH HHS K01 MH121580
6 · The paper itself

Abstract

Objectives: Bipolar disorder (BD) has been associated with an elevated risk of Alzheimer's Disease (AD). We assessed AD biomarkers in BD and tested whether epigenetic aging (EA) acceleration is a potential mechanism driving variability in these markers. Design Setting Participants: Cross-sectional study of n=59 living individuals with BD and n=20 age- and sex-equated control participants, as well as analyses of postmortem brain samples (Brodmann area 9/46) from n=46 individuals with BD. Measurements: Amyloid beta (Aβ) Results: Individuals with BD showed an increase in Aβ Conclusions: Our results provide preliminary evidence that EA may explain the variability in AD risk in individuals with BD and could act as a target for preventing dementia and AD in BD.

Indexed as

accelerated agingAlzheimer’s diseaseamyloid betabipolar disorderepigenetic aging

Identifiers

PMID40297439
PMCPMC12036414

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.