ArticleDose-response : a publication of International Hormesis Society
Alterations of DNA Repair and Immune Infiltration in Radiation-Induced Intestinal Injury.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The intestine exhibits high radiosensitivity and is susceptible to damage during radiotherapy for abdominal or pelvic tumors, especially at radiation doses exceeding 5 Gy, which can lead to severe gastrointestinal complications. This study aims to elucidate the mechanisms of DNA repair and immune responses in radiation-induced intestinal injury, with the goal of enhancing radiotherapy efficacy. Methods: We employed weighted correlation network analysis (WGCNA) to analyze RNA sequencing data from intestinal tissues collected at various time points following irradiation, as well as from mice with targeted disruption of the NFE2-like bZIP transcription factor 2 (Nrf2) gene and their wild-type counterparts. Results: Our analysis revealed enhanced DNA repair capacity and attenuated immune response 3.5 days after irradiation. Histone variants and ribosomal proteins were identified as potential contributors to DNA repair processes. We also constructed a competing endogenous RNAs (ceRNA) network including genes from both the DNA repair and immune modules and identified Akr1b8, Gsta3, and Nqo1 as radiation-effect genes regulated by Nrf2. Conclusions: These findings provide valuable insights into the molecular mechanisms of radiation-induced intestinal injury and suggest potential targets for protecting normal intestinal tissue during radiotherapy. This knowledge may contribute to improved treatment outcomes and enhanced patient well-being.
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