Evidence map›Paper›PMID 40298034›Full record

ArticleAnnals of medicine2025

Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia.

Lassi Kaartinen, Tiina Jääskeläinen, Eeva Sliz, Gamze Yazgeldi Gunaydin, Satu Wedenoja, Shintaro Katayama, Eero Kajantie, Valtteri Rinne, Seppo Heinonen, Juha Kere and 6 more

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Lassi KaartinenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Tiina JääskeläinenMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1202-0936
Eeva SlizResearch Unit of Population Health, University of Oulu, Oulu, Finland.
Gamze Yazgeldi GunaydinStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Satu WedenojaStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Shintaro KatayamaStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Eero KajantieMedical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
Valtteri RinneAdmescope (Symeres Finland Ltd), Oulu, Finland.
Seppo HeinonenObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juha KereStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Heta MerikallioResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Hannele Laivuori submitted on behalf of FINNPEC group
Eeva Sliz
submitted on behalf of FinnGen group
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3212-7826
Janne HukkanenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0003-4981-0525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit with oxysterol 4β-hydroxycholesterol (4βHC) acting as a hypotensive factor MATERIALS AND

methodsThis study investigated the association between maternal plasma 4βHC, blood pressure (BP) indices, placental expression of LXR target genes, and patient characteristics using data from the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort. Plasma samples of 144 women with PE and 38 healthy pregnant controls as well as 44 PE and 40 control placental samples were available. In addition, genetic data from the FinnGen project was utilized to explore the associations of LXR alleles with PE and pregnancy hypertension.

resultsThere were no significant associations between 4βHC and BP or maternal and perinatal characteristics in FINNPEC cohort. However, plasma 4βHC was inversely correlated with the maternal body mass index. There were no associations with the genetic variants of LXRs with PE in FinnGen. LXR target genes APOD, SCARB1, TGM2, and LPCAT3 were expressed differently between PE and normal pregnancies in placental samples of FINNPEC.

conclusionsOur results demonstrate that plasma 4βHC and genetic LXR variants do not play a major role in PE and BP regulation during pregnancy. However, key LXR target genes involved in lipid metabolism were expressed differently in normal and PE pregnancies. Further research is needed to understand the complexities of oxysterols, LXRs, and their potential contributions to placental function and pregnancy outcomes.

Indexed as

HydroxycholesterolsLiver X ReceptorsPre-EclampsiaAdultAllelesBlood PressureBody Mass IndexCase-Control StudiesFemaleFinlandHumansPlacentaPolymorphism, Single NucleotidePregnancycholest-5-ene-3,4-diolHydroxycholesterolsLiver X Receptors4β-hydroxycholesterolLiver X receptoroxysterolplacentapre-eclampsia

Identifiers

PMID40298034
PMCPMC12042236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.