Evidence map›Paper›PMID 40298463›Full record

ReviewAntibiotics (Basel, Switzerland)2025

Research Progress on the Antibacterial Activity of Natural Flavonoids.

Zhijin Zhang, Mingze Cao, Zixuan Shang, Jing Xu, Xu Chen, Zhen Zhu, Weiwei Wang, Xiaojuan Wei, Xuzheng Zhou, Yubin Bai and 1 more

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Bioactive Profile, Antioxidant, andAntioxidants (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Microbiology spectrum · 2026
    Article
  19. Article
  20. Antibacterial activity of epigallocatechin gallate againstFrontiers in veterinary science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhijin ZhangKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Mingze CaoCollege of Life Science and Food Engineering, Hebei University of Engineering, Congtai District, Handan 056038, China.
Zixuan ShangKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Jing XuKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Xu ChenKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Zhen ZhuCollege of Life Science and Food Engineering, Hebei University of Engineering, Congtai District, Handan 056038, China.
Weiwei WangKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Xiaojuan WeiKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Xuzheng ZhouKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Yubin BaiKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.
Jiyu ZhangKey Laboratory of New Animal Drug Project of Gansu Province, Lanzhou 730050, China.

Funding

The Central Public-interest Scientific Institution Basal Research Fund 1610322024016The earmarked fund for CARS CARS-37The grants from the National Natural Science Foundation of China 32202860The Innovation Project of Chinese Academy of Agricultural Sciences 25-LZIHPS-05The Key Research and Development Projects of Hebei 22326617DThe Natural Science Foundation of Hebei Province C2024402032The Science and Technology Plan Project of Gansu Province 24JRRA028
6 · The paper itself

Abstract

The use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing phytochemicals, have gained significant research interest for their diverse biological activities and antibacterial effects on various drug-resistant bacteria. This review summarizes the latest research progress on flavonoids, with a particular focus on several flavonoids exhibiting certain antibacterial activity, and explores their antibacterial mechanisms, including disruption of cell membranes and cell walls, inhibition of proteins and nucleic acids, interference with signal transduction, suppression of efflux pump activity, and inhibition of biofilm formation and virulence factor production. Additionally, we have reviewed the synergistic combinations of flavonoids with antibiotics, such as the combination of quercetin with colistin or EGCG with tetracycline, which significantly enhance therapeutic efficacy.

Indexed as

antibacterial activityantibacterial mechanismmultidrug-resistant bacterianatural flavonoidssynergistic effects

Identifiers

PMID40298463
PMCPMC12023951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.