Evidence map›Paper›PMID 40298906›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery.

Hang Zhao, Bo Yu, Dingyi Yu, Ting Ji, Kexin Nie, Jingyi Tian, Xinchen Shen, Kaiyue Zhang, Junhan Ou, Xinyi Yang and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hang ZhaoCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0006-7619-6072
Bo YuCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0004-8750-1701
Dingyi YuCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0002-7578-7883
Ting JiCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-6242-1412
Kexin NieCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0001-5969-0750
Jingyi TianCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0008-6514-2946
Xinchen ShenCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0001-7053-1240
Kaiyue ZhangCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0009-7080-2766
Junhan OuCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0003-7149-7907
Xinyi YangCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0006-4171-9750
Dongfang XiaoCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0009-0005-5074-6550
Qi ZhouDeanery of Biomedical Sciences, Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID https://orcid.org/0000-0003-3560-2311
Wenwen HuangCentre for Regeneration and Cell Therapy, The Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-8175-9083

Funding

Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China LHDMZ22H300004National Natural Science Foundation of China 52003233
6 · The paper itself

Abstract

Magnetic soft robots have the potential to revolutionize the field of drug delivery owing to their capability to execute tasks in hard-to-reach regions of living organisms. Advancing their functionality to perform active drug delivery and related tasks necessitates the innovation of smart substrate materials that satisfy both mechanical and biocompatibility requirements while offering stimuli-responsive properties. Optimization of the interaction between the substrate and magnetic components is also critical as it ensures robust actuation of the robot in complex physiological environments. To address these issues, a facile strategy is presented that synergistically combines genetic programming and electrochemical engineering to achieve on-demand drug release with protein-magnetite soft robots. As the substrate of the robot, genetically engineered silk-elastin-like protein (SELP) is encoded with thermo-responsive motifs, serving as the dynamic unit to respond to temperature changes. Ultrafine magnetite (Fe

Indexed as

Drug Delivery SystemsElectrochemical TechniquesRoboticsAnimalsMagnetite NanoparticlesMagnetite Nanoparticlesde novo protein designelectrochemical engineeringin situ crystallizationstimuli‐responsive hydrogelssuperparamagnetic soft robots

Identifiers

PMID40298906
PMCPMC12279187

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.