ArticleeLife2025
An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo.
Cora Demler, John C Lawlor, Ronit Yelin, Dhana Llivichuzcha-Loja, Lihi Shaulov, David Kim, Megan Stewart, Frank K Lee, Natalia Shylo, Paul A Trainor and 2 more
Abstract read
In one paragraphArticle in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Ronit YelinDepartment of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Dhana Llivichuzcha-LojaDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Lihi ShaulovRappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
David KimDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Megan StewartDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Frank K LeeDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Natalia ShyloStowers Institute for Medical Research, Kansas City, United States.
Thomas M SchultheissDepartment of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Funding
Mechanisms underlying form and function of the contractile gut lymphaticsR01DK092776 · NIDDK · CORNELL UNIVERSITY · PI Natasza A Kurpios · 2012 to 2026
$5.6MGut-specific lymphatic patterns and progenitor heterogeneity during intestinal health and diseaseR01DK107634 · NIDDK · CORNELL UNIVERSITY · PI KURPIOS, NATASZA A · 2017 to 2021
$2.0MBroad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834kZeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500kEvolutionary mechanisms of gastrulation and left-right patterning in amniotes.K99HD114881 · NICHD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI SHYLO, NATALIA · 2024 to 2025
$200kIsrael Science Foundation 1463/16Israel Science Foundation 1528/22March of Dimes Foundation 1-FY11-520National Institute of Child Health and Human Development HD114881National Science Foundation DGE-1650441NCRR NIH HHS S10 RR025502NICHD NIH HHS K99 HD114881NIDDK NIH HHS R01 DK092776NIDDK NIH HHS R01DK092776NIDDK NIH HHS R01 DK107634NIDDK NIH HHS R01DK107634NIH HHS S10 OD018516NIMHD NIH HHS L60 MD003100
6 · The paper itselfAbstract
Correct intestinal morphogenesis depends on the early embryonic process of gut rotation, an evolutionarily conserved program in which a straight gut tube elongates and forms into its first loops. However, the gut tube requires guidance to loop in a reproducible manner. The dorsal mesentery (DM) connects the gut tube to the body and directs the lengthening gut into stereotypical loops via left-right (LR) asymmetric cellular and extracellular behavior. The LR asymmetry of the DM also governs blood and lymphatic vessel formation for the digestive tract, which is essential for prenatal organ development and postnatal vital functions including nutrient absorption. Although the genetic LR asymmetry of the DM has been extensively studied, a divider between the left and right DM has yet to be identified. Setting up LR asymmetry for the entire body requires a
Indexed as
Basement MembraneBody PatterningGastrointestinal TractIntestinesAnimalsChick EmbryoGene Expression Regulation, Developmentalchickendevelopmental biologydorsal mesenteryextracellular matrixgutleft-right asymmetrymidline barrierorganogenesis
Identifiers
PMID40298919
PMCPMC12040318
What Socratic holds
Textmetadata
LicenceCC BY
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