Evidence map›Paper›PMID 40298968›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts.

Patricia da Silva Pantoja Newman, Amandeep Bajwa, Agnese De Mario, Cristina Mammucari, Salvatore Mancarella

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patricia da Silva Pantoja NewmanDepartment of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-4621-7059
Amandeep BajwaDepartment of Surgery, Transplant Research Institute, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0003-0517-8871
Agnese De MarioDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Cristina MammucariDepartment of Biomedical Sciences, University of Padua, Padua, Italy.ORCID 0000-0003-3220-9610
Salvatore MancarellaDepartment of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-9049-4697

Funding

Defining the roles of Orai3 channel in cardiomyocytes and cardiomyopathy.R01HL153638 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MANCARELLA, SALVATORE · 2020 to 2022
$1.1M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R073037538NHLBI NIH HHS R01 HL153638
6 · The paper itself

Abstract

Cardiac fibroblasts (CFs) play a crucial role in regulating normal heart function and are also involved in the pathological remodeling of the heart that occurs due to hypertension, myocardial infarction, and heart failure. Metabolic changes in fibroblasts are key drivers in the progression of these diseases. Calcium (Ca

Indexed as

Calcium Channel BlockersEnergy MetabolismFibroblastsMyocardiumORAI1 ProteinAnimalsCalciumCalcium SignalingCells, CulturedEndoplasmic ReticulumGlucoseHomeostasisMaleMiceCalciumCalcium Channel BlockersGlucoseORAI1 ProteincalciumfibroblastfibrosismetabolismOrai

Identifiers

PMID40298968
PMCPMC12220785

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.