Evidence map›Paper›PMID 40299202›Full record

ArticleTranslational stroke research2025

ADAMTS- 1 rs402007 Polymorphism Modulates Carotid Plaque Vulnerability and Atorvastatin Efficacy in Cerebral Infarction Patients.

Yongjian Liu, Yongmin Deng, Zhixing Du, Shuowen Zhang, Litao Chen, Xiaojing Yan, Yongbin Pei

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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongjian Liu *Health Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China.
Yongmin Deng *Pediatric Department, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Zhixing DuHealth Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China.
Shuowen ZhangHealth Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China.
Litao ChenHealth Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China.
Xiaojing YanHealth Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China. 408498506@qq.com.
Yongbin PeiHealth Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050000, Hebei Province, China. pyb-1977@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the association between rs402007 polymorphism in the ADAMTS-1 gene and carotid atherosclerotic plaque vulnerability, as well as the lipid-lowering efficacy of atorvastatin in cerebral infarction patients. Clinical data from 684 cerebral infarction patients admitted to The First Hospital of Hebei Medical University (2016-2019) were analyzed. Patients were stratified into stable plaque (n = 338) and vulnerable plaque (n = 346) groups based on carotid ultrasound. General information, biochemical markers, rs402007 (G/C) genotypes (dominant model), and allele frequencies were compared. Polymorphism genotyping was performed using TaqMan SNP assays (Applied Biosystems) on an ABI 7500 Fast Real-Time PCR system. Logistic regression evaluated plaque vulnerability risk factors and gene-risk factor interactions. Atorvastatin's lipid-lowering efficacy was compared across genotypes. Diabetes prevalence, LDL-C, TC, HCY, and FIB levels differed significantly between groups (P < 0.05). Genotypic distribution analysis revealed a higher frequency of the GG genotype in the stable plaque group (29.59% vs. 21.68%, χ

Indexed as

Anticholesteremic AgentsAtorvastatinCarotid Artery DiseasesCerebral InfarctionPlaque, AtheroscleroticAgedFemaleGenotypeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPolymorphism, Single NucleotideTreatment OutcomeAnticholesteremic AgentsAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsADAMTS- 1 geneAtorvastatinCarotid atherosclerosisCerebral infarctionPharmacogenetics

Identifiers

PMID40299202

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.