Evidence map›Paper›PMID 40299205›Full record

ArticleCell biochemistry and biophysics2025

Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies.

K Ramakrishnan, Reshma Rajan, Lenin Nachimuthu, Premkumar Jayaraj, Chandrakala A Narasimhulu, Pragney Deme, Sanjay Rajagopalan, Akella Sivaramakrishna, S Karthikeyan, Rajagopal Desikan

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K RamakrishnanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Reshma RajanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Lenin NachimuthuDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Premkumar JayarajDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Chandrakala A NarasimhuluBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Pragney DemeDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sanjay RajagopalanDepartment of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Akella SivaramakrishnaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
S KarthikeyanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Rajagopal DesikanDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India. desikanrajagopal@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of diabetes as a major non-communicable disease underscores the critical need for effective anti-diabetic agents. The new analogs designed 3a-3j were effectively synthesised and thoroughly characterised using (

Indexed as

alpha-AmylasesEnzyme InhibitorsGlycoside Hydrolase InhibitorsMolecular Docking SimulationAntioxidantsCatalytic DomainHumansHypoglycemic Agentsalpha-AmylasesAntioxidantsEnzyme InhibitorsGlycoside Hydrolase InhibitorsHypoglycemic AgentsAnti-inflammationAntioxidantDiabetesHDLIn silico dockingLDL

Identifiers

PMID40299205

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.