Evidence map›Paper›PMID 40299673›Full record

ArticleBiomedicines2025

Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats.

Jun-Seok Sung, Il-Gyu Ko, Lakkyong Hwang, Sang-Hoon Kim, Jin Hee Han, Jung Won Jeon, Sae Rom Kim, Jeong Mi Lee, Cheon Woong Choi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun-Seok SungDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Il-Gyu KoResearch Support Center, School of Medicine, Keimyung University, Deagu 42601, Republic of Korea.ORCID 0000-0003-2696-6869
Lakkyong HwangDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Sang-Hoon KimDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers, The Stat University of New Jersey, Piscataway, NJ 08901, USA.ORCID 0000-0002-8867-8822
Jin Hee HanDepartment of Anesthesiology and Pain Medicine, Kyung Hee Medical Center, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Jung Won JeonDepartment of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.
Sae Rom KimDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.ORCID 0000-0001-9041-0457
Jeong Mi LeeDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.ORCID 0009-0002-0565-7178
Cheon Woong ChoiDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.ORCID 0000-0002-2536-6151

Funding

National Research Foundation of Korea NRF- 2022R1A2B5B01002219
6 · The paper itself

Abstract

Increased exposure to particulate matter (PM) from air pollution causes lung inflammation and increases morbidity and mortality due to respiratory diseases. Pirfenidone is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis.

Indexed as

bronchoalveolar lavage fluidinflammationparticulate matterpirfenidonepulmonary fibrosis

Identifiers

PMID40299673
PMCPMC12025220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.