Evidence map›Paper›PMID 40299703›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Behavioral resilience via dynamic circuit firing homeostasis.

Adam Hoagland, Ryan Schultz, Zerong Cai, Zachary L Newman, Ehud Y Isacoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam HoaglandDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Ryan SchultzHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720.
Zerong CaiDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Zachary L NewmanDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0003-4775-9359

Funding

Synaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6M
Optical Stimulation MicroscopeS10RR028971 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2011 to 2011
$596k
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS107506NCRR NIH HHS S10 RR028971NINDS NIH HHS R01 NS107506
6 · The paper itself

Abstract

Homeostatic regulation ensures stable neural circuit output under changing conditions. We find that in

Indexed as

Behavior, AnimalDrosophila melanogasterHomeostasisMotor NeuronsAnimalsDrosophilaLarvaLocomotionSynapsesglutamatergichomeostasislocomotionmotor neuronsynapse

Identifiers

PMID40299703
PMCPMC12067288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.