Evidence map›Paper›PMID 40299764›Full record

ArticleThe Journal of general virology2025

Characterization of human cytomegalovirus infection dynamics in human microglia.

Marcos Nuevalos Guaita, Tajudeen O Jimoh, Emma B Barrall, Kristina E Atanasoff, Michelle E Ehrlich, Sam Gandy, Estéfani García-Ríos, Pilar Perez Romero, J Andrew Duty, Domenico Tortorella

Abstract read
In one paragraph

Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcos Nuevalos GuaitaNational Center for Microbiology, Instituto de Salud Carlos III. Majadahonda, Madrid, Spain.
Tajudeen O JimohDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emma B BarrallDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristina E AtanasoffDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle E EhrlichDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sam GandyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Estéfani García-RíosInstituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Valencia, Spain.
Pilar Perez RomeroDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA.
J Andrew DutyCenter for Therapeutic Antibody Development, Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Domenico TortorellaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Fanny M Elahi · 2020 to 2026
$31.0M
Integrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0M
TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)RF1AG059319 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2018 to 2018
$4.2M
Use of iPSC systems to define roles of microglial TREM2/DAP12 and CR3/DAP12 complexes and their genetic variants in specifying risk for late onset sporadic Alzheimer's diseaseR01AG061894 · NIA · NEW YORK STEM CELL FOUNDATION · PI FOSSATI, VALENTINA, GANDY, SAMUEL E. · 2018 to 2022
$4.2M
Integrated understanding of complex viral network biology in Alzheimer's DiseaseRF1AG058469 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2019 to 2019
$4.1M
Identification of human cytomegalovirus life cycle stage-specific therapeuticsR01AI139258 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2019 to 2022
$1.6M
Optimization of novel inhibitors of human cytomegalovirusR56AI175974 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2024 to 2024
$684k
Human CMV monoclonal antibodies as therapeutics to inhibit virus infection and disseminationR56AI174062 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2023 to 2023
$684k
Delineating the mechanism and inhibitory capacity of CMV neutralizing antibodiesR21AI147632 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2020 to 2021
$465k
NIAID NIH HHS R01 AI139258NIAID NIH HHS R21 AI147632NIAID NIH HHS R56 AI174062NIAID NIH HHS R56 AI175974NIAID NIH HHS T32 AI007647NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG061894NIA NIH HHS RF1 AG058469NIA NIH HHS RF1 AG059319NIA NIH HHS U01 AG046170
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a β-herpesvirus that establishes asymptomatic infections in immunocompetent individuals but can cause severe or even life-threatening symptoms in immunocompromised patients. HCMV can replicate in a wide variety of cells through the engagement of diverse cell factors with the viral envelope protein gH/gL/gO (trimer) or gH/gL/UL128/UL130/UL131a (pentamer), allowing for systemic spread within the human host. This study explores HCMV infection tropism and dynamics in human microglia, demonstrating the susceptibility of microglia to both clinical and laboratory HCMV strains,

Indexed as

CytomegalovirusCytomegalovirus InfectionsMicrogliaCell LineHumansViral Envelope ProteinsViral TropismVirus InternalizationVirus ReplicationViral Envelope Proteinsantibodiesentry inhibitorshuman cytomegalovirusmicroglianeuropilin-2 (NRP-2)tropism

Identifiers

PMID40299764
PMCPMC12041478

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.