ArticlePloS one2025
Zinc selenide (ZnSe) nanoparticle coated with green seaweed (Ulva fasciata) hydroalcoholic extract as an anti-leishmanial compound on Leishmania major.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study focused on evaluating the effectiveness of zinc selenide nanoparticles coated with green seaweed (Ulva fasciata) (ZnSe-Uf) against Leishmania major (L. major) in light of increasing drug resistance in the treatment of cutaneous leishmaniasis and the growing necessity for new therapeutic options. Key characteristics of ZnSe-Uf, including shape, size, functional groups, zeta potential, and polydispersity index, were analyzed in detail. The study investigated the effects of different concentrations of ZnSe-Uf compared to meglumine antimoniate (MA; used as the control), on both the promastigote and amastigote forms of L. major, calculating the selectivity index (SI) for each. Analysis revealed that the dominant functional group in ZnSe-Uf was C-H stretching, attributed to polysaccharides, lipids, and proteins. The size of ZnSe-Uf ranged from 228.2-242.8 nm (P = 0.37), with a polydispersity index of 0.31-0.33 (P = 0.85), and a zeta potential ranging from -35.6 mV to -57.9 mV (P = 0.07) over a period of 90 days. The lethal concentration 50 (LC50) for ZnSe-Uf was 7.61 μg/mL, while for MA it was 17.37 μg/mL on promastigote (P = 0.03). On amastigote, the LC50 was 24.3 μg/mL for ZnSe-Uf and 12.3 μg/mL for MA (P = 0.04). The SI was 27.55 for ZnSe-Uf and 41.26 for MA (P = 0.02). The lower LC50 for MA on amastigote indicated its better effectiveness on L. major compared to ZnSe-Uf, suggesting that ZnSe-Uf may have a lower ability to concentrate in macrophages compared to MA. However, ZnSe-Uf still showed anti-leishmanial activity and was non-toxic to macrophages (SI > 10), indicating the need for further investigation on animal models.
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