Evidence map›Paper›PMID 40300047›Full record

ArticleGenesis (New York, N.Y. : 2000)2025

Excluding the Genomic Location of Pax2 Regulatory Elements for the Developing Mouse Eye.

Tzu-Hua Ho, Daniela Santamaria-Munoz, Hollin Hamelynck, Anna La Torre, Tom Glaser, Nadean L Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tzu-Hua HoDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
Daniela Santamaria-MunozDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
Hollin HamelynckDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
Anna La TorreDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
Tom GlaserDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.ORCID 0000-0003-1000-2301
Nadean L BrownDepartment of Cell Biology and Human Anatomy, University of California, Davis, California, USA.ORCID 0000-0002-4906-4625

Funding

Homeotic hotspot in the human genome for eye and brain diseaseR01EY033742 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Thomas M. Glaser · 2022 to 2026
$2.2M
Optic Stalk-Disc Development and DifferentiationR01EY033729 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BROWN, NADEAN L · 2022 to 2025
$1.4M
National Institutes of Health (NIH) R01-EY033729National Institutes of Health (NIH) R01-EY033742National Institutes of Health (NIH) R21-NS133564NEI NIH HHS R01 EY033729NEI NIH HHS R01 EY033742
6 · The paper itself

Abstract

The Pax2 transcription factor is activated uniformly in the optic vesicle/cup, but becomes progressively restricted to the forming optic disc and stalk. In the eye, it is not known how Pax2 expression is regulated and progressively restricted, in part because no Pax2 regulatory elements have been identified for this organ. Multiple Pax2-Cre mouse transgenic lines have been produced, but essentially none of these Cre recombinase drivers are active in the visual system. Only Tg(BAC-Pax2-cre)

Indexed as

EyePAX2 Transcription FactorAnimalsEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalIntegrasesMiceMice, TransgenicRetinaCre recombinaseIntegrasesPax2 protein, mousePAX2 Transcription FactorastrocyteBAC transgenic mouseCre drivereyeoptic stalkPax2retina

Identifiers

PMID40300047
PMCPMC12040291

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.