ArticleInternational archives of allergy and immunology2026
Sex Differences in Lung B Cell Responses in a Murine Model of Asthma.
Article in International archives of allergy and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.Cell reports · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
introductionAsthma demonstrates a strong sex bias. B cells play critical roles in the pathogenesis of allergic inflammation, including allergen-specific immunoglobulin production. The sex-specific responses of B cell subsets in allergic lung inflammation remain unknown. This project aimed to study the sex differences in allergen-induced B cell subsets in a murine model of asthma.
methodsAdult mice of both sexes were sensitized using two intraperitoneal injections of ovalbumin (OVA) on days 0 and 7. Mice were then challenged with intranasal OVA on days 14, 16, and 18 and euthanized 24 h after the last challenge. We examined whole-lung B-cell subsets using flow cytometry and whole-lung cytokine levels using ELISA or multiplex assay.
resultsOVA-treated female mice had significantly higher numbers of whole-lung naïve B cells and plasmablasts versus OVA-treated male mice. The numbers of IgM+ memory B cells and isotype-switched IgM- memory B cells in the lung trended higher in OVA-treated female mice. The lungs of OVA-treated female mice had increased C-C motif chemokine ligand 5, granulocyte-colony stimulating factor, IL-1β, and tumor necrosis factor-α protein levels, chemokines/cytokines involved in B-cell regulation, versus lungs from OVA-treated male mice. However, whole-lung B cell activating factor and a proliferation-inducing ligand levels showed no differences between male and female mice.
conclusionsIn a murine asthma model, sex differences in whole-lung B lymphocytes are primarily driven by higher numbers of naïve B cells and plasmablasts in females versus males. Our results suggest that sex chromosomes and sex hormones may influence B-cell subsets during allergic lung inflammation.
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