Metformin × glycemic control

SynthesisDiabetes & metabolism journal2025

Initial Pharmacological Strategies in People with Early Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-Analysis.

Jong Han Choi et al.PubMed ↗Full text ↗Publisher ↗

  • Metformin+dipeptidyl peptidase-4 inhibitorslooks good hereLower long-term blood sugar.Randomised, small.
  • Metformin+glucagon-like peptide-1 receptor agonists (GLP-1RA)no clear effectLower long-term blood sugar.Nothing cleared the noise.

What the trial testedrandomised · 2025

Randomised vs monotherapy

Probably lowered long-term blood sugar

−1.46percentage points−1.96 to −0.95

Metformin+dipeptidyl peptidase-4 inhibitors vs monotherapy

As reported

difference −1.46 %, 95% CI −1.96 to −0.95 · the paper's word: change in HbA1c

Not counted

Probably lowered long-term blood sugar

−1.50percentage points−2.04 to −0.96

Metformin+glucagon-like peptide-1 receptor agonists (GLP-1RA) vs monotherapy

As reported

difference −1.50 %, 95% CI −2.04 to −0.96 · the paper's word: change in HbA1c

Who was studied, and how

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

Metformin+glucagon-like peptide-1 receptor agonists (GLP-1RA)
monotherapy

Probably lowered long-term blood sugar−1.50

randomised

The trial randomly assignedassigned by chance

Metformin+dipeptidyl peptidase-4 inhibitors
monotherapy

Probably lowered long-term blood sugar−1.46

randomised

the abstract, start to end

(weighted mean difference [WMD] -1.50%; 95% confidence interval [CI] -2.04 to -0.96) and metformin+dipeptidyl peptidase-4 inhibitors (WMD -1.46%; 95% CI, -1.96 to -0.95) were

← favours treatmentfavours comparator →
could be chance
Change in HbA1cMetformin+glucagon-like peptide-1 receptor agonists (GLP-1RA) vs monotherapy
−1.50−2.04 to −0.96
Change in HbA1cMetformin+dipeptidyl peptidase-4 inhibitors vs monotherapy
−1.46−1.96 to −0.95
MetforminGLP-1 receptor agonistsGlycemic control
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2 papers cite it

2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40300775