Evidence map›Paper›PMID 40301028›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Treatment of Anti-myelin-associated Glycoprotein Neuropathy with Tirabrutinib and a 3-year Follow-up.

Chinami Yuzawa, Masateru Tajiri, Maho Usuda, Akira Matsushima, Minori Kodaira, Nagaaki Katoh, Yoshiki Sekijima

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chinami YuzawaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Masateru TajiriDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Maho UsudaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Akira MatsushimaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Minori KodairaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Nagaaki KatohDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Yoshiki SekijimaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 69-year-old man was admitted to our hospital because of progressive numbness in the lower legs and fingertips as well as a burning sensation in the soles of both feet. The patient was diagnosed with anti-myelin-associated glycoprotein (anti-MAG) neuropathy based on increased serum IgM levels and anti-MAG antibody titers. Atypical pulmonary mycobacteriosis was also suspected. Following treatment with tirabrutinib (a second-generation Bruton tyrosine kinase inhibitor), his symptoms improved and the anti-MAG antibody titer and IgM levels decreased. Tirabrutinib may therefore be an effective treatment option for anti-MAG neuropathy, particularly in patients at risk of infection.

Indexed as

Myelin-Associated GlycoproteinPyrimidinesAgedAutoantibodiesFollow-Up StudiesHumansImmunoglobulin MMaleProtein Kinase InhibitorsTreatment OutcomeAutoantibodiesImmunoglobulin MMyelin-Associated GlycoproteinProtein Kinase InhibitorsPyrimidinesanti-myelin-associated glycoprotein neuropathyBruton tyrosine kinase inhibitorrituximabtirabrutinib

Identifiers

PMID40301028
PMCPMC12589174

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.