Evidence map›Paper›PMID 40301262›Full record

ReviewAdvances in experimental medicine and biology2025

Sperm DNA Fragmentation and Fertility.

Jessica Marinaro, Peter N Schlegel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jessica MarinaroDepartment of Urology, Weill Cornell Medicine, New York, NY, USA. Jessica.Marinaro@SGFertility.com.
Peter N SchlegelNew York Mens Health Medical, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated levels of sperm deoxyribonucleic acid (DNA) fragmentation (SDF) have been associated with several adverse reproductive outcomes, including: lower natural and assisted reproductive technology (ART) pregnancy rates, abnormal embryo development, and recurrent pregnancy loss. However, due to conflicting study results, limited high-level evidence, multiple clinically available assays, and variable standard reference ranges, precisely how SDF testing should be applied to the evaluation and treatment of infertile men remains controversial. To better understand SDF and its role in clinical practice, this chapter aims to: (1) review the literature that has made SDF such a controversial topic, (2) discuss newly published evidence contributing to this complex discussion, and (3) outline the most recent practice guidelines currently available.

Indexed as

DNA FragmentationFertilityInfertility, MaleSpermatozoaFemaleHumansMalePregnancyReproductive Techniques, AssistedAssisted reproductionAssisted reproductive technology (ART)Male infertilitySemen analysis (SA)Sperm DNA fragmentation (SDF)

Identifiers

PMID40301262

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.