Evidence map›Paper›PMID 40301290›Full record

ArticleJournal of imaging informatics in medicine2026

Super-Resolution Deep Learning Reconstruction for T2*-Weighted Images: Improvement in Microbleed Lesion Detection and Image Quality.

Yusuke Asari, Koichiro Yasaka, Kazuki Endo, Jun Kanzawa, Naomasa Okimoto, Yusuke Watanabe, Yuichi Suzuki, Shiori Amemiya, Shigeru Kiryu, Osamu Abe

Abstract read
In one paragraph

Article in Journal of imaging informatics in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yusuke AsariDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Koichiro YasakaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan. koyasaka@gmail.com.ORCID http://orcid.org/0000-0002-0324-6562
Kazuki EndoDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Jun KanzawaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Naomasa OkimotoDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Yusuke WatanabeDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Yuichi SuzukiDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Shiori AmemiyaDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.
Shigeru KiryuDepartment of Radiology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita, Chiba, 286 - 0124, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7 - 3- 1 Hongo, Bunkyo-Ku, Tokyo, 113 - 8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Super-resolution deep learning reconstruction (SR-DLR) is a promising tool for improving image quality by enhancing spatial resolution compared to conventional deep learning reconstruction (DLR). This study aimed to evaluate whether SR-DLR improves microbleed detection and visualization in brain magnetic resonance imaging (MRI) compared to DLR. This retrospective study included 69 patients (66.2 ± 13.8 years; 44 females) who underwent 3 T brain MRI with T2*-weighted 2D gradient echo and 3D flow-sensitive black blood imaging (reference standard) between June and August 2024. T2*-weighted images were reconstructed using SR-DLR and DLR. Three blinded readers detected microbleeds and assessed image quality, including microbleed and normal structure visibility, sharpness, noise, artifacts, and overall quality. Quantitative analysis involved measuring signal intensity along the septum pellucidum. Microbleed detection performance was analyzed using jackknife alternative free-response receiver operating characteristic analysis, while image quality was analyzed using the Wilcoxon signed-rank test and paired t-test. SR-DLR significantly outperformed DLR in microbleed detection (figure of merit: 0.690 vs. 0.645, p < 0.001). SR-DLR also demonstrated higher sensitivity for microbleed detection. Qualitative analysis showed better microbleed visualization for two readers (p < 0.001) and improved image sharpness for all readers (p ≤ 0.008). Quantitative analysis revealed enhanced sharpness, especially in full width at half maximum and edge rise slope (p < 0.001). SR-DLR improved image sharpness and quality, leading to better microbleed detection and visualization in brain MRI compared to DLR.

Indexed as

Cerebral HemorrhageDeep LearningImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingAgedAged, 80 and overBrainFemaleHumansMaleMiddle AgedRetrospective StudiesImage qualityMagnetic resonance imagingMicrobleed

Identifiers

PMID40301290
PMCPMC12920851

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.