Evidence map›Paper›PMID 40301685›Full record

ArticleCommunications chemistry2025

Enhanced sensitivity to odors due to chemosignals associated with anxiety.

Annkatrin Wunder, Nele Bürkel, Imke Guder, José I Zorzin, Christiane Mühle, Helene M Loos, Jessica Freiherr

Abstract read
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Annkatrin WunderFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054, Erlangen, Germany. annkatrin.wunder@fau.de.ORCID http://orcid.org/0000-0002-7591-6705
Nele BürkelFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054, Erlangen, Germany.
Imke GuderFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054, Erlangen, Germany.
José I ZorzinFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital Erlangen, Department of Conservative Dentistry and Periodontology, Glueckstrasse 11, 91054, Erlangen, Germany.
Christiane MühleFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0001-7517-9154
Helene M LoosFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Chair of Aroma and Smell Research, Department of Chemistry and Pharmacy, Henkestrasse 9, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-9112-5735
Jessica FreiherrFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054, Erlangen, Germany. jessica.freiherr@fau.de.ORCID http://orcid.org/0000-0001-9052-4497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemocommunication is important in human nonverbal communication. Behavioral effects of anxiety chemosignals on recipients are established but it is unknown whether odor sensitivity can be modulated by such stimuli. We tested recipients' sensitivity to phenylethyl alcohol (PEA) and n-butanol after exposure to anxiety chemosignals, neutral chemosignals and blank condition. As fourth condition, a horror movie was shown, to compare the effects of visual stimuli and chemosignals on odor sensitivity. Odor sensitivity for PEA was significantly increased by anxiety chemosignals compared to blank condition. No change in odor sensitivity was evident for n-butanol. We also investigated the composition of the applied chemosensory stimuli using untargeted one-dimensional gas chromatography-mass spectrometry (GC-MS) and -olfactometry (GC-O). Considering GC-MS data, several compounds were found with significantly higher normalized peak areas in anxiety sweat samples compared to the neutral samples. GC-O analysis indicated that the carboxylic acids dodecanoic acid and 3-hydroxy-3-methylhexanoic acid were potential main contributors to the odor of anxiety sweat samples, whereby tetradecanoic acid and patchouli alcohol were those of the odor of neutral sweat samples. This study provides evidence that anxiety chemosignals can improve odor sensitivity and constitutes a further step toward elucidating the composition of sweat samples used in chemical communication research.

Identifiers

PMID40301685
PMCPMC12041518

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.