Evidence map›Paper›PMID 40301995›Full record

ArticleStem cell research & therapy2025

Targeting prominin-2/BACH1/GLS pathway to inhibit oxidative stress-induced ferroptosis of bone mesenchymal stem cells.

Yuzhu Xu, Lele Zhang, Xuanfei Xu, Yuao Tao, Pengfei Xue, Yuntao Wang, Renjie Chai, Xiaotao Wu

Abstract read
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuzhu XuDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China.
Lele ZhangDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China.
Xuanfei XuDepartment of Nuclear Medicine, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, Jiangsu, China.
Yuao TaoDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China.
Pengfei XueDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China.
Yuntao WangDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China.
Renjie ChaiZhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Southeast University, Nanjing, 210009, Jiangsu, China.
Xiaotao WuDepartment of Spine Center, Zhongda Hospital, Medical School, Southeast University, No. 87 DingJiaQiao, GuLou District, Nanjing City, 210009, Jiangsu Province, China. wuxiaotaospinal@163.com.ORCID http://orcid.org/0009-0002-8376-0808

Funding

National Natural Science Foundation of China 82372473
6 · The paper itself

Abstract

Suppressing bone mesenchymal stem cell (BMSC) ferroptosis is expected to optimize BMSCs-based therapy for intervertebral disc degeneration (IVDD). Our previous study revealed that Prominin-2 could protect against ferroptosis by decreasing cellular Fe

Indexed as

AC133 AntigenBasic-Leucine Zipper Transcription FactorsFerroptosisGlycoproteinsMesenchymal Stem CellsOxidative StressAnimalsHumansMaleMesenchymal Stem Cell TransplantationMiceRatsSignal Transductiontert-ButylhydroperoxideAC133 AntigenBasic-Leucine Zipper Transcription FactorsGlycoproteinstert-ButylhydroperoxideBone marrow mesenchymal stem cells (BMSCs)BTB and CNC homolog 1 (BACH1)FerroptosisGlutaminase kidney isoformMitochondrial (GLS)Prominin-2

Identifiers

PMID40301995
PMCPMC12042394

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.