Evidence map›Paper›PMID 40302043›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

A comparative study of the EAT-Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance.

Jessica Samuelsson, Anna Stubbendorff, Anna Marseglia, Olof Lindberg, Caroline Dartora, Sara Shams, Nira Cedres, Silke Kern, Johan Skoog, Lina Rydén and 2 more

Abstract readComparative Study
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Association of the Planetary Health Diet with dementia risk and brain pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica SamuelssonNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0002-8891-6720
Anna StubbendorffDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Anna MarsegliaDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Olof LindbergDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Caroline DartoraDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Sara ShamsDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Nira CedresDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Silke KernNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.
Johan SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.
Lina RydénNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.
Eric WestmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Ingmar SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.

Funding

Alzheimerfonden AF-554461Alzheimerfonden AF-647651Alzheimerfonden AF-737641Alzheimerfonden AF-743701Alzheimerfonden AF-842471Alzheimerfonden AF-844671Alzheimerfonden AF-929959Alzheimerfonden AF-930868Alzheimerfonden AF-939825Alzheimerfonden AF-940139Alzheimerfonden AF-968441Alzheimerfonden AF-980935Center for Innovative Medicine FoUI-988254David och Astrid Hageléns Stiftelse 0005David och Astrid Hageléns Stiftelse 2020-02372David och Astrid Hageléns Stiftelse FS-2022Demensfonden KI-Dnr 4-1759/2024Gun och Bertil Stohnes StiftelseHjärnfonden FO2014-0207Hjärnfonden FO2016-0214Hjärnfonden FO2018-0214Hjärnfonden FO2019-0163Hjärnfonden FO2020-0235Hjärnfonden FO2024-0097Hjärnfonden FO2024-0341-HK-76KI Research Foundation Grants 2024-2025 2024-02580Konung Gustaf V:s och Drottning Victorias FrimurarestiftelseLindhés AdvokatbyråLoo och Hans Ostermans Stiftelse för Medicinsk Forskning 2022-01255Loo och Hans Ostermans Stiftelse för Medicinsk Forskning 2023-01645Loo och Hans Ostermans Stiftelse för Medicinsk Forskning 2024-02166Stiftelsen för Gamla Tjänarinnor 2020-00946Stiftelsen för Gamla Tjänarinnor 2023-085Stiftelsen Handlanden Hjalmar Svenssons HJSV2024031Stiftelsen Psykiatriska forskningsfondenStiftelsen Wilhelm och Martina LundgrenSwedish Research Council for Health, Working Life and Welfare 2013-1202Swedish Research Council for Health, Working Life and Welfare 2013-2496Swedish Research Council for Health, Working Life and Welfare 2018-00471Swedish Research Council for Health, Working Life and Welfare 2024-00210Swedish Research Council for Health, Working Life and Welfare AGECAP2013-2300the Eivind och Elsa K:son Sylvans stiftelseThe Foundation for Geriatric Diseases at Karolinska Institutet 2022-01268The Foundation for Geriatric Diseases at Karolinska Institutet 2023-01598The Foundation for Geriatric Diseases at Karolinska Institutet 2024-02114The Foundation for Geriatric Diseases at Karolinska Institutet FS-2022-0008The Swedish Research Council 2012-5041The Swedish Research Council 2013-8717The Swedish Research Council 2015-02830The Swedish Research Council 2017-00639The Swedish Research Council 2019-01096The Swedish Research Council 2019-02075The Swedish Research Council 2019-02075-15The Swedish Research Council 2022-00882The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALF716681The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALF965812The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-1005471The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-771071The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-81392The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALFGBG-965923
6 · The paper itself

Abstract

backgroundThe impact of the sustainable EAT-Lancet planetary health diet on brain and cognitive health remains unclear. This study compared the impact of the EAT-Lancet diet with the well-established cognitive-beneficial Mediterranean diet (MeDi) in relation to neuroimaging biomarkers and cognitive performance among older adults.

methodsThe study included 615 dementia-free 70-year-olds from the Swedish population-based Gothenburg H70 Birth Cohort study. Dietary adherence was measured with EAT-Lancet diet and MeDi scores. Neuroimaging measures included cortical thickness, hippocampal volume, small vessel disease, and deep learning-derived brain age. Cognitive performance was assessed with a global cognitive composite score.

resultsIn multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance. DISCUSSION: The results indicate the beneficial effects of both the EAT-Lancet and the MeDi on brain health. HIGHLIGHTS: There were no indications of detrimental effects of adhering to the EAT-Lancet diet. Adhering to the EAT-Lancet planetary health diet was associated with thicker cortex. Results confirm links between the Mediterranean diet and better cognitive function.

Indexed as

BrainCognitionDiet, HealthyDiet, MediterraneanNeuroimagingAgedAlzheimer DiseaseBiomarkersCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsSwedenBiomarkersAlzheimer's diseasebrain agecognitive impairmentEAT‐Lancet dietMediterranean dietneuroimagingsmall vessel disease

Identifiers

PMID40302043
PMCPMC12040733

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.