Evidence map›Paper›PMID 40303087›Full record

ArticleTransboundary and emerging diseases2024

The VP1 Protein of Porcine Teschovirus Inhibits the Innate Immune Response to Viral Infection by Blocking MDA5 Activation.

Yuying Li, Xinyu Zhang, Baopeng Zhao, Chenchen Zhao, Xiaoxiao Lei, Haixin Huang, Chengkai Li, Min Zheng, Tian Lan, Wenchao Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Porcine Teschovirus 2 3CMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuying LiCollege of Animal Sciences, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China.ORCID https://orcid.org/0000-0003-3717-7726
Xinyu ZhangInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.ORCID https://orcid.org/0009-0004-7070-0843
Baopeng ZhaoInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Chenchen ZhaoInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Xiaoxiao LeiInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Haixin HuangInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Chengkai LiInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Min ZhengGuangxi Center for Disease Prevention and Control, Nanning, Guangxi 530001, China.
Tian LanInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Wenchao SunInstitute of Virology, Wenzhou University, Wenzhou, Zhejiang 325035, China.ORCID https://orcid.org/0000-0002-8845-6242
HuiJun LuChangchun Veterinary Research Institute, Jilin Academy of Agricultural Sciences, Changchun, Jilin 130000, China.ORCID https://orcid.org/0000-0003-4532-4466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine teschovirus (PTV) can cause reproductive dysfunction and respiratory diseases, with high mortality rates for sick pigs. Among Picornaviridae family virus-encoded proteins, the VP1 structural protein is critical for viral immune evasion. However, whether PTV VP1 inhibits the type I interferon (IFN) response remains unknown. Here, it shows that the PTV VP1 protein significantly hinders the activation of NF-

Indexed as

Capsid ProteinsImmunity, InnateInterferon-Induced Helicase, IFIH1Picornaviridae InfectionsSwine DiseasesTeschovirusAnimalsNF-kappa BSendai virusSwineCapsid ProteinsInterferon-Induced Helicase, IFIH1NF-kappa B

Identifiers

PMID40303087
PMCPMC12017125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.