Evidence map›Paper›PMID 40303402›Full record

ArticleFrontiers in immunology2025

Supersulfide controls intestinal inflammation by suppressing CD4

Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao and 9 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shunichi TayamaDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yuya KitamuraDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kyoga HiraideDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hibiki SuzukiDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Jing LiDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ziying YangDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ryoji MitsuwakaDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Akihisa KawajiriDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kosuke SatoDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Feng GaoDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Taku NakaiApplied Oxygen Physiology Project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
Yuko OkuyamaDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tadahisa NumakuraDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Mitsuhiro YamadaDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tomoaki IdaOrganization for Research Promotion, Osaka Metropolitan University, Sakai, Japan.
Masanobu MoritaDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takeshi KawabeDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takaaki AkaikeDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Naoto IshiiDepartment of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4

Indexed as

CD4-Positive T-LymphocytesColitisGlutathioneInflammatory Bowel DiseasesSulfidesAnimalsCell ProliferationDisease Models, AnimalHumansInflammationLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutGlutathioneSulfidesCd4 + t cellcell cyclecell proliferationinflammatory bowel diseasesupersulfide metabolism

Identifiers

PMID40303402
PMCPMC12037617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.