Evidence map›Paper›PMID 40304047›Full record

ArticleCirculation. Cardiovascular quality and outcomes2025

Association of Alzheimer's Disease and Related Dementias (ADRD) With Days at Home Among Medicare Beneficiaries After a Heart Failure Hospitalization.

Hannah W Mitlak, Cisco G Espinosa, Michael P Thompson, Kathleen A Ryan, Deborah A Levine, Na Sun, Raya E Kheirbek, Madeline R Sterling, Jason Falvey

Abstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hannah W MitlakDepartment of Medicine, Weill Cornell Medicine, New York, NY (H.W.M., C.G.E., M.R.S.).
Cisco G EspinosaDepartment of Medicine, Weill Cornell Medicine, New York, NY (H.W.M., C.G.E., M.R.S.).ORCID 0000-0002-0756-2255
Michael P ThompsonDepartment of Cardiac Surgery, University of Michigan Medical School, Ann Arbor, MI (M.P.T.).ORCID 0000-0002-9992-593X
Kathleen A RyanDepartment of Medicine, (K.A.R.), University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0003-1158-8455
Deborah A LevineDepartment of Medicine, University of Michigan Medical School, Ann Arbor, MI (D.A.L.).ORCID 0000-0002-6864-8001
Na SunDepartment of Physical Therapy and Rehabilitation Science, (N.S., J.F.), University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0002-6149-3465
Raya E KheirbekDivision of Geriatrics and Palliative Medicine, Department of Medicine (R.E.K.), University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0003-0755-1940
Madeline R Sterling *Department of Medicine, Weill Cornell Medicine, New York, NY (H.W.M., C.G.E., M.R.S.).ORCID 0000-0002-9928-4407
Jason Falvey *Department of Physical Therapy and Rehabilitation Science, (N.S., J.F.), University of Maryland School of Medicine, Baltimore, MD.

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
I-TRANSFER-HF: Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe: A Type 1 Hybrid Effectiveness Implementation TrialR01HL169312 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Madeline R Sterling · 2023 to 2026
$3.1M
The ENRICH Study: Engaging Community and Municipal Services to Promote High Quality Aging in Place After Hip FractureK76AG074926 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI FALVEY, JASON RAYMOND · 2021 to 2025
$1.4M
Leveraging Home Health Aides to Improve Outcomes in Heart FailureK23HL150160 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI STERLING, MADELINE R · 2020 to 2024
$921k
NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K23 HL150160NHLBI NIH HHS R01 HL169312NIA NIH HHS K76 AG074926
6 · The paper itself

Abstract

backgroundOlder adults with concomitant heart failure (HF) and Alzheimer's Disease and Related Dementias (ADRD) are at high risk for adverse outcomes, including health care utilization and mortality. Increasingly, adults with these conditions want to maximize quality of life and days at home (DAH). This study aimed to determine the association between ADRD and DAH following HF hospitalization.

methodsThis retrospective cohort analysis draws from a 20% random sample from 2017 to 2019 Medicare claims of beneficiaries who survived HF hospitalization. The primary outcome was mean DAH 6 months post-hospitalization. Exposure was defined as the presence of diagnosed ADRD, extracted from the Master Beneficiary Summary Base File Chronic Conditions subfile. Multivariable negative binomial regression was used to examine the adjusted association between ADRD and DAH, with covariates selected in accordance with the Andersen model of health care utilization.

resultsThe 74,908 Medicare beneficiaries in the cohort had a mean age of 79.1 years (SD 11); half were men (50.0%) and 82.3% were non-Hispanic White. Overall, 18% (n=14,396) had ADRD. Beneficiaries with concomitant ADRD were older, more likely to be female, and more likely to have dual Medicaid/Medicare eligibility compared with those without ADRD. Although DAH in the 6 months preceding admission was similar, following hospitalization those with concomitant ADRD had less time at home (mean DAH 120.7 [65.9] for those with ADRD versus 136.4 [59.7] for those without ADRD). When adjusting for patient characteristics, hospitalization course, and hospital and geographic-level fixed effects, this difference persisted: patients with HF and ADRD spent an estimated 6% fewer DAH post-hospitalization (incidence rate ratio, 0.94 0.93-0.95). In the 6 months post-hospitalization, 10.2% of patients with HF and ADRD spent ≤7 DAH. The odds of spending ≤7 DAH were 24% higher for patients with ADRD (odds ratio, 1.24 [95% CI, 1.16-1.33]).

conclusionsFollowing HF hospitalization, Medicare beneficiaries with ADRD spent significantly fewer DAH than those without ADRD. Identifying and addressing the unmet needs of this population after hospitalization is crucial.

Indexed as

Alzheimer DiseaseDementiaHeart FailureHome Care ServicesHospitalizationMedicareAgedAged, 80 and overAge FactorsFemaleHumansMalePatient Acceptance of Health CareQuality of LifeRetrospective StudiesRisk Assessmentaging in placeAlzheimer diseaseheart failureodds ratiopatient-centered outcomes researchquality in lifetransition of care

Identifiers

PMID40304047
PMCPMC12173780

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.