ReviewCurrent stem cell research & therapy2025
Multiple Stem/Progenitor Cells Isolated from the Limbus.
Review in Current stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Influence of fluid shear stress on human limbal epithelial cells.Biochemistry and biophysics reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limbal epithelial stem cells (LESCs), which are responsible for the renewal and repair of corneal epithelium, are located in the limbus. The limbus is an important structure for maintaining the normal corneal epithelium. Damage to the limbus can lead to limbal stem cell deficiency (LSCD), a common blind-causing disease. However, the cellular composition of the limbus and the functions of various cell populations have not yet been accurately reproduced, making it difficult to reconstruct the normal structure of the limbus under disease conditions. Currently, there are mature methods for isolating and culturing various types of stem/progenitor cells from the limbus, including LESCs, limbal niche cells (LNCs), and limbal melanocytes (LMs). Successful culture of these cells helps to better investigate their biological functions, their role in sustaining corneal epithelial homeostasis, and their feasibility for basic research or clinical applications. This review summarizes the definitions, functions, and characteristics of these three types of stem/progenitor cells that can be isolated and purified from the limbus, in the hope of drawing attention to and stimulating discussion on this topic. This will help to clarify the cellular composition of the limbus, reconstruct the normal structure of the limbus, and develop innovative stem cell therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.