Evidence map›Paper›PMID 40304362›Full record

ArticleExpert opinion on therapeutic targets

Defeating kinases that promote tumorigenesis through non-catalytic functions with PROTACs - PIM kinase as an example.

Pedro Torres-Ayuso, John Brognard

Abstract readEditorial
In one paragraph

Article in Expert opinion on therapeutic targets. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pedro Torres-AyusoDepartment of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
John BrognardLaboratory of Cell and Developmental Signaling, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Oncogenic Kinases in CancerZIABC011691 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BROGNARD, JOHN · 2016 to 2025
$14.4M
Yale Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck CancerP50DE030707 · NIDCR · YALE UNIVERSITY · PI BURTNESS, BARBARA · 2020 to 2024
$11.8M
"Role of Amplified Protein Kinases in Head and Neck Squamous Cell Carcinoma Progression and Therapy Resistance."R03DE033064 · NIDCR · TEMPLE UNIV OF THE COMMONWEALTH · PI TORRES-AYUSO, PEDRO · 2023 to 2023
$317k
Intramural NIH HHS ZIA BC011691NCI NIH HHS P30 CA006927NIDCR NIH HHS P50 DE030707NIDCR NIH HHS R03 DE033064
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancerPIM kinaseprecision medicinePROTAC

Identifiers

PMID40304362
PMCPMC12085992

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.