Evidence map›Paper›PMID 40304792›Full record

ReviewMolecular biology reports2025

Modulation of host Rab GTPases by Salmonella: mechanisms of immune evasion and intracellular replication.

Dandan Ding, Jiayin Guo, Hui Sun, Jing Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dandan DingCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, 730030, China.
Jiayin GuoCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, 730030, China.
Hui SunCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, 730030, China.
Jing YangCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, 730030, China. yangjing0502@lzu.edu.cn.

Funding

Cuiying Scientific and Technological Innovation Program of The Second Hospital & Clinical Medical School, Lanzhou University CY2021-MS-A05Lanzhou University Medical Graduate Training Innovation and Development Program lzuyxcx-2022-140National Natural Science Foundation of China 82102431Talent Introduction Plan of The Second Hospital & Clinical Medical School, Lanzhou University yjrckyqdj-2021-03The Fundamental Research Funds for the Central Universities lzujbky-2023-eyt04
6 · The paper itself

Abstract

Salmonella is one of the major pathogens responsible for foodborne illnesses worldwide, characterized by diverse serotypes and a broad host range. As an intracellular bacterium, Salmonella invades host cells and establishes a protected niche known as the Salmonella-containing vacuoles (SCVs), which provide a suitable environment for intracellular survival. Rab GTPases, key regulators of intracellular membrane trafficking, play a crucial role in the biogenesis and dynamics of SCVs. Through its type III secretion systems (T3SSs), Salmonella delivers a repertoire of effector proteins into host cells, which modulate the activity of Rab GTPases and alter membrane trafficking to facilitate SCVs formation and maintenance. This review summarizes recent advances in understanding how Salmonella effectors manipulate Rab GTPases to promote intracellular survival and evade host innate immune responses.

Indexed as

Immune Evasionrab GTP-Binding ProteinsSalmonellaSalmonella InfectionsAnimalsBacterial ProteinsHost-Pathogen InteractionsHumansImmunity, InnateProtein TransportType III Secretion SystemsVacuolesBacterial Proteinsrab GTP-Binding ProteinsType III Secretion SystemsEffector proteinsHost immune defenseIntracellular survivalRab GTPaseSalmonellaSalmonella-containing vacuoles (SCVs)

Identifiers

PMID40304792

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.