ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025
Structural Characterization and Protective Effect Against Myocardial Fibrosis of Polysaccharide from Stellariae Radix (Stellaria Dichotoma L. Var. lanceolata Bge.).
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Natural Products Targeting Myocardial Fibrosis: Pharmacological Basis, Molecular Mechanisms and Translational Barriers.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Myocardial fibrosis is the main pathological feature of cardiovascular diseases. Stellariae Radix polysaccharide has many pharmacological effects, but its anti-cardiac fibrosis activity has not been reported. In this study that the structure of a new polysaccharide SRP-1 from Stellariae Radix was identified, and its anti-myocardial fibrosis effect was discussed. SRP-1 was extracted from Stellariae Radix and purified by DEAE-52 cellulose chromatography. According to physicochemical methods and monosaccharide composition analysis, SRP-1 was found to be mainly composed of galactose, glucose, xylose, fructose, mannose, and rhamnose, and its weight average molecular weight (Mw) was 31,309 Da. Tests of activity against myocardial fibrosis indicated marked downregulation of the expression of Col I, Col III, α-SMA, and proteins related to the TGF-β/Smad signaling pathway, which were induced by TGF-β1, in mouse cardiac fibroblasts pretreated with SRP-1. In addition, SRP-1restrained the abnormal growth of cardiac fibroblasts cells and the expression of Snail 1, Snail 2, Twist 1, and Slug mRNA in vitro. These results indicate that Stellariae Radix polysaccharide may warrant further analysis as a novel therapeutic agent for cardiovascular diseases.
Indexed as
Identifiers
40304797What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.