Evidence map›Paper›PMID 40305106›Full record

ArticleMolecular biology of the cell2025

VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex.

Li Zhang, Tunahan Uygun, Hye Jee Hahn, Yejun Liu, Pilar Rivero-Ríos, Dazhi Li, Vikas Navratna, Emily Bristow, Guangming Luo, Anna Kovarzin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Li ZhangLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-2738-1494
Tunahan UygunLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Hye Jee HahnLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Yejun LiuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Pilar Rivero-RíosLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Dazhi LiDepartment of Cell Biology, Yale University, New Haven, CT 06520.
Vikas NavratnaLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Emily BristowLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Guangming LuoLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Anna KovarzinLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Yuxia BoDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa K1N 6N5, Canada.
Suresh GaddeDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa K1N 6N5, Canada.
Marceline CôtéDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa K1N 6N5, Canada.
Dennis C KoDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710.
Shyamal MosalagantiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Karin M ReinischDepartment of Cell Biology, Yale University, New Haven, CT 06520.
Lois S WeismanLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.

Funding

Regulation of myosin V interaction with cargo-Equipment SupplementR01GM062261 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lois S Weisman · 2001 to 2026
$5.8M
Regulation of parallel recycling pathways at synaptic sitesR01NS129198 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Mark Alexander Sutton, Lois S Weisman · 2022 to 2026
$2.4M
NIGMS NIH HHS R01 GM062261NINDS NIH HHS R01 NS129198
6 · The paper itself

Abstract

The PIKfyve-VAC14-FIG4 complex synthesizes and turns over phosphatidylinositol-3,5-bisphosphate, PI(3,5)P

Indexed as

HexosyltransferasesMembrane ProteinsPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiae ProteinsVesicular Transport ProteinsCryoelectron MicroscopyFlavoproteinsHumansIntracellular Signaling Peptides and ProteinsMutationPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesProtein BindingProtein MultimerizationSaccharomyces cerevisiaeFAB1 protein, S cerevisiaeFIG4 protein, humanFlavoproteinsHexosyltransferasesIntracellular Signaling Peptides and ProteinsMembrane Proteinsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)PIKFYVE protein, humanSaccharomyces cerevisiae ProteinsVAC14 protein, humanVesicular Transport Proteins

Identifiers

PMID40305106
PMCPMC12260172

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.