Evidence map›Paper›PMID 40305274›Full record

ArticleBiomolecules2025

Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide.

Şükrü Ateş, Harun Ülger, Sümeyye Uçar, Aslı Okan, Mert Ocak, Ecma Güvenilir, Zeynep Yılmaz Şükranlı, Emin Kaymak, Züleyha Doğanyiğit, Serpil Taheri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Analysis of Pharmacological Properties ofLife (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Şükrü AteşDepartment of Anatomy, Faculty of Medicine, Erciyes University, Kayseri 38280, Turkey.ORCID 0000-0001-7096-2481
Harun ÜlgerDepartment of Anatomy, Faculty of Medicine, Erciyes University, Kayseri 38280, Turkey.
Sümeyye UçarDepartment of Anatomy, Faculty of Medicine, Erciyes University, Kayseri 38280, Turkey.ORCID 0000-0003-3378-3745
Aslı OkanDepartment of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Mert OcakDepartment of Basic Medical Sciences, Anatomy, Faculty of Dentistry, Ankara University, Ankara 06100, Turkey.ORCID 0000-0001-6832-6208
Ecma GüvenilirBetul Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38280, Turkey.
Zeynep Yılmaz ŞükranlıBetul Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38280, Turkey.
Emin KaymakDepartment of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Züleyha DoğanyiğitDepartment of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Serpil TaheriBetul Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38280, Turkey.
Seher YilmazDepartment of Anatomy, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.ORCID 0000-0003-4551-995X

Funding

Erciyes University Scientific Research Projects Coordinator (ERÜ Bilimsel Araştırma Projeleri Birimi) TDK-2023-12753
6 · The paper itself

Abstract

The onset of Alzheimer's disease (AD) is attributed to widespread amyloid beta (Aβ) plaque accumulation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. However, the underlying mechanism of AD remains unclear, and no curative treatment currently exists. The aim was to investigate the effect of thymoquinone by suppressing the RAGE/NOX4 pathway in AD. Mice (

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBenzoquinonesBrainNADPH Oxidase 4Peptide FragmentsReceptor for Advanced Glycation End ProductsAnimalsDisease Models, AnimalMaleMiceOxidative StressSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-42)BenzoquinonesNADPH Oxidase 4Nox4 protein, mousePeptide FragmentsReceptor for Advanced Glycation End ProductsthymoquinoneAlzheimer’s diseasebrain anatomymicro CTNOX4RAGEthymoquinone

Identifiers

PMID40305274
PMCPMC12024666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.