Evidence map›Paper›PMID 40305282›Full record

ReviewBiomolecules2025

Stimulus-Transcription Coupling of TRPM3 Channels: A Signaling Pathway from the Plasma Membrane to the Nucleus.

Gerald Thiel, Oliver G Rössler

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gerald ThielDepartment of Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland University, Building 44, 66421 Homburg, Germany.ORCID 0000-0001-9163-8242
Oliver G RösslerDepartment of Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland University, Building 44, 66421 Homburg, Germany.

Funding

Saarland University LOM-T201000492
6 · The paper itself

Abstract

Transient receptor potential melastatin-3 (TRPM3) channels are cation channels activated by heat and chemical ligands. TRPM3 regulates heat sensation, secretion, neurotransmitter release, iris constriction, and tumor promotion. Stimulation of TRPM3 triggers an influx of Ca

Indexed as

Cell MembraneCell NucleusSignal TransductionTranscription, GeneticTRPM Cation ChannelsAnimalsHumansTRPM3 protein, humanTRPM Cation Channelscalcineurincalmodulinepigenetic regulatorsextracellular signal-regulated protein kinaseGPCRphosphatidylinositol 4,5-bisphosphatetranscription factorZn

Identifiers

PMID40305282
PMCPMC12025076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.