ReviewBiochimica et biophysica acta. Molecular and cell biology of lipids2025
Recent advances in carotenoid absorption, distribution, and elimination.
Review in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dietary Carotenoid Intake and Sleep: A Narrative Review of Evidence from Human and In Vivo Animal Studies.Nutrients · 2026Review
- Bioactive Properties of Carotenoids in Ocular Diseases: Antioxidant, Anti-Inflammatory, and Neuroprotective Effects.Nutrients · 2026Review
- Carotenoid bioavailability in humans reflects the mammalian nocturnal bottleneck: a position paper.Journal of clinical biochemistry and nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Carotenoids are a class of pigments with antioxidant properties synthesized by photosynthetic and heterotrophic organisms. Humans can store carotenoids in their intact form or cleave them enzymatically to apocarotenoids such as vitamin A, a hormone-like nutrient with crucial roles in gene expression and vision. Clinical and preclinical studies suggest that the consumption of diets rich in carotenoids attenuate cardiometabolic diseases, some types of cancer, neurodegenerative disorders, and inflammatory conditions. The bioactive properties of carotenoids depend, at least in part, on their accumulation in target tissues. However, the pathways that drive carotenoid absorption, delivery, and accumulation in tissues remain largely uncharacterized. This review provides a critical overview of the experimental models utilized to monitor carotenoid homeostasis in mammals. We also delve into recent findings concerning carotenoid intestinal uptake, bodily distribution, cellular uptake, and intracellular trafficking. Finally, we discuss the physiological relevance of a fecal carotenoid elimination pathway that operates independently of carotenoid enzymatic cleavage. Establishing the players governing carotenoid biodistribution and elimination is essential to maximize the bioactive properties of carotenoids in humans to prevent chronic diseases.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.