Evidence map›Paper›PMID 40307224›Full record

ArticleNature communications2025

A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis.

Xiaotong Jiang, Amanda M Koenig, Berkley J Walker, Jianping Hu

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Move over endosymbionts, peroxisomes pass electrons too.Biochemical Society transactions · 2025
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaotong JiangMichigan State University-Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-2849-9208
Amanda M KoenigMichigan State University-Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0009-0007-6514-3589
Berkley J WalkerMichigan State University-Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0001-5932-6468
Jianping HuMichigan State University-Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI, USA. huji@msu.edu.ORCID http://orcid.org/0000-0002-4635-4299

Funding

DOE | SC | Basic Energy Sciences (BES) DE-FG02-91ER20021National Science Foundation (NSF) MCB 2148206
6 · The paper itself

Abstract

Photorespiration functions in part to support photosynthetic performance, especially under stress such as high light, yet the underlying mechanisms are poorly understood. To identify modulators of photorespiration under high light, we have isolated genetic suppressors of the photorespiratory mutant hpr1 (hydroxypyruvate reductase 1) from Arabidopsis. A suppressor that partially rescues hpr1 is mapped to GLYR1, which encodes the cytosolic glyoxylate reductase 1 that converts glyoxylate to glycolate. Independent glyr1 mutants also partially rescue hpr1 and another photorespiratory mutant, catalase 2. Our genetic, transcriptomic and metabolic profiling analyses together reveal a connection between cytosolic glyoxylate and a non-canonical photorespiratory route mediated by HPR2, which we name the photorespiratory glyoxylate shunt. This shunt complements the canonical photorespiratory pathway and is especially critical when high photorespiratory fluxes are required and when the major photorespiratory pathway is deficient. Our findings support the metabolic flexibility of photorespiration and may help to improve crop performance under stress.

Indexed as

ArabidopsisArabidopsis ProteinsCytosolGlyoxylatesPhotosynthesisAlcohol OxidoreductasesGene Expression Regulation, PlantGlycolatesHydroxypyruvate ReductaseLightMutationAlcohol OxidoreductasesArabidopsis ProteinsGlycolatesglycolic acidglyoxylate reductaseGlyoxylatesglyoxylic acidHydroxypyruvate Reductase

Identifiers

PMID40307224
PMCPMC12043991

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.