ArticleNature immunology2025
Aberrant T follicular helper cells generated by T
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- The Impact of Oral-Gut Microbiota Structure and Its Manipulation on RA Development and Management.Food science & nutrition · 2026Review
- PD-1MedComm · 2026Article
- Host-Microbiome Immune Interaction Networks: A Comparative Evolutionary Perspective Across Worms, Mice, and Humans.Pathogens (Basel, Switzerland) · 2026Review
- Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026Review
- Multiomics-guided discovery of protective microbiome signatures in lupus-prone mice treated with Faecalibacterium prausnitzii.Nature communications · 2026Article
- The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026Review
- Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs.bioRxiv : the preprint server for biology · 2026Article
- Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood.bioRxiv : the preprint server for biology · 2026Article
- Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology.European journal of immunology · 2026Article
- Gut dysbiosis in difficult-to-treat rheumatoid arthritis: hypothesized microbial endotypes, persistent inflammation, and pharmacological treatment resistance.Frontiers in pharmacology · 2026Review
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- Autoimmune disease-associated pathobionts: mechanisms and therapeutic potential of phage-based approaches.Frontiers in immunology · 2026Review
- More than a leaky gut: how gut priming shapes arthritis.Nature reviews. Rheumatology · 2025Review
- Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Tingting FanDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Chi TaiDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kiah C SleimanDepartment of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-5171-931X
Madeline P CutcliffeDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Haram KimDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ye LiuDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jianying LiDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Gang XinDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Mollyanna GrashelDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Laurie BaertDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8309-7132
Chinwe EkeochaDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Paige VergenesDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Svetlana LimaJill Roberts Center and Institute for Research in Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA.
Wan-Lin LoDivision of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-9074-6847
Judith LinDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6118-5086
Beatriz HanaokaDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Trevor N TankersleyDepartment of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Min WangDepartment of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing, China.
Xuan ZhangDepartment of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing, China.ORCID http://orcid.org/0000-0001-8775-1699
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9589-2360
Wael JarjourDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Randy LongmanJill Roberts Center and Institute for Research in Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, USA.
Hsin-Jung Joyce WuDivision of Rheumatology and Immunology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. joyce.wu2@osumc.edu.ORCID http://orcid.org/0009-0009-6050-0350
Funding
Tfh cells: linking the gut microbiota to a gut-distal autoimmune diseaseR01AI107117 · NIAID · UNIVERSITY OF ARIZONA · PI Hsin-Jung Joyce Wu · 2014 to 2026
$4.9MMicrobiota Control Lung Th17 Cell Response and Plasticity Leading to Autoimmune Lung DiseaseR01HL148347 · NHLBI · UNIVERSITY OF ARIZONA · PI WU, HSIN-JUNG JOYCE · 2020 to 2023
$1.8MDivision of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI107117NHLBI NIH HHS R01 HL148347NIAID NIH HHS R01 AI107117U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL148347
Abstract
Much remains unknown regarding T follicular helper 17 (T
Indexed as
AutoimmunityCell PlasticityT Follicular Helper CellsTh17 CellsAnimalsArthritis, RheumatoidB-LymphocytesGastrointestinal MicrobiomeGerminal CenterHumansMiceMice, Inbred C57BLPeyer's Patches
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.