Evidence map›Paper›PMID 40307644›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Methodology and Practice for Studying Crosstalk Between 3D Human Tissue Models in Pneumatically Actuated Multi-Organ-on-Chip Systems.

Jibbe Keulen, Aurino Kemas, Sonia Youhanna, Reza Zandi Shafagh, Volker M Lauschke

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jibbe KeulenDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Aurino KemasDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Sonia YouhannaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Reza Zandi ShafaghDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Volker M LauschkeDr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. volker.lauschke@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug development landscape is challenged by low success rates, largely due to the translational gap between effects observed in pre-clinical models and drug responses in clinical trials. Microphysiological systems (MPS) have the potential to narrow this gap by addressing some of the limitations of conventional static in vitro models, such as phenotypical irrelevance and lack of complexity. This is accomplished by integrating state-of-the-art microfluidics and bioengineering to better recapitulate tissue function and inter-organ crosstalk. Here, we describe the use of a multi-organ MPS for the culture of organotypic tissues. The system has been extensively optimized and benchmarked for assessing both short- and long-term dynamics and provides a low-absorption environment ideal for drug development.

Indexed as

Lab-On-A-Chip DevicesMicrofluidicsModels, BiologicalHumansTissue EngineeringMicrophysiological systemsOrgan-on-a-chipOrganotypic cultureTissue crosstalk

Identifiers

PMID40307644

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.