ArticleBMC plant biology2025
Comprehensive analysis of cinnamoyl-CoA reductase (CCR) gene family in wheat: implications for lignin biosynthesis and stress responses.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Identification and In Vitro Functional Characterization of thePlants (Basel, Switzerland) · 2026Article
- Genome-Wide Characterization and Expression Profiling of theLife (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis of the Cinnamoyl-CoA Reductase (CCR) Gene Family and Its Involvement in Lignin Biosynthesis and Stress Responses in Six Tea Plant Cultivars.International journal of molecular sciences · 2026Article
- Mining of genes and pathways associated with endoplasmic reticulum stress in Brassica campestris via RNA-Seq.Plant cell reports · 2026Article
- Rice Cinnamoyl CoA Reductase-like GenePlants (Basel, Switzerland) · 2025Article
- Article
- VyMYB258, A MYB Transcription Factor From Vitis yanshanensis, Enhances Drought Tolerance by Activating the Lignin Biosynthesis Pathway.Physiologia plantarumArticle
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6 authors.
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Abstract
backgroundLignin, the second most abundant terrestrial biopolymer, represents a significant renewable natural biomaterial. Cinnamoyl-CoA reductase (CCR) catalyzes the conversion of various hydroxycinnamoyl-CoA esters into their corresponding aldehydes, utilizing NADPH as a cofactor. CCR functions as a regulatory point that controls the overall carbon flux towards lignin and constitutes the initial committed step in the lignin biosynthesis pathway. Additionally, CCR plays a crucial role in plant development and in resistance to biotic and abiotic stresses. Bread wheat (Triticum aestivum L.), a hexaploid crop, serves as a staple food for much of the global population. However, the copy number variation and expression characteristics of wheat CCR genes remain to be elucidated.
resultsThis study identified 115 unique members of the CCR gene family through a comprehensive search of the wheat genome database. Subsequent analyses included the physicochemical properties, chromosomal localizations, gene duplication events, and structures of these genes. Wheat CCRs were categorized into TaCCR and TaCCR-like genes based on phylogenetic comparison, sequence alignment, and protein three-dimensional structure analysis. Twenty TaCCR proteins, characterized by key amino acid residues at the protein catalytic and NADPH-binding sites, were identified as genuine TaCCRs, potentially playing significant roles in lignin biosynthesis. The expression patterns of these 20 TaCCR genes were investigated in various wheat tissues and seedlings subjected to biotic and abiotic stresses. These genes may significantly influence stem development and responses to heat, drought, salt, and pathogen stresses. Additionally, degradome data analysis suggested that the expression of TaCCR6D-1 was regulated by miRNAs. Virus-induced gene silencing experiments demonstrated the involvement of TaCCR5-5 and TaCCR6-1 in wheat lignin synthesis.
conclusionsThis study presents the first comprehensive identification and analysis of wheat CCR genes. Our findings establish a foundation for further elucidation of TaCCR functions and offer a significant genetic resource for future wheat improvement efforts.
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