Evidence map›Paper›PMID 40307728›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Innate immune training in the neonatal response to sepsis.

Jaimar C Rincon, Dayuan Wang, Valerie E Polcz, Evan L Barrios, Marvin L Dirain, Ricardo F Ungaro, Dina C Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A Efron and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Maladaptive trained immunity in viral infections.The Journal of clinical investigation · 2025
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jaimar C RinconSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA. jaimar.rincon@surgery.ufl.edu.ORCID 0000-0002-4611-106X
Dayuan WangDepartment of Biostatistics, University of Florida Colleges of Medicine and Public Health and Health Sciences, Gainesville, FL, USA.
Valerie E PolczSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Evan L BarriosSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Marvin L DirainSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Ricardo F UngaroSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Dina C NacionalesSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Leilani Zeumer-SpataroSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Feifei XiaoDepartment of Biostatistics, University of Florida Colleges of Medicine and Public Health and Health Sciences, Gainesville, FL, USA.
Philip A EfronSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Lyle L MoldawerSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Guoshuai CaiSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.
Shawn D LarsonSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100119, Gainesville, FL, 32610 - 0019, USA.

Funding

Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Prevention of Neonatal Sepsis by Therapeutic Targeting of MDSCsR01GM143143 · NIGMS · UNIVERSITY OF FLORIDA · PI LARSON, SHAWN DAVID · 2022 to 2025
$1.5M
NIGMS NIH HHS R01 GM143143NIGMS NIH HHS R01GM143143NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have beneficial, non-specific effects (NSEs) against secondary infections to unrelated pathogens. These beneficial effects have been attributed to trained immunity, and emergency granulopoiesis plays an essential role. However, trained immunity has been shown to affect multiple myeloid subsets and how trained immunity influences the host protective response is still undefined. Here we show that Bacillus-Calmette-Guérin (BCG) vaccination improves survival to polymicrobial sepsis by simultaneously reprogramming broad aspects of myelopoiesis. Specifically, BCG vaccination expands multiple myeloid subsets, including the lineage (Lin)

Indexed as

BCG VaccineImmunity, InnateSepsisAnimalsAnimals, NewbornMiceMice, Inbred C57BLMyeloid CellsMyelopoiesisVaccinationBCG VaccineBCGMyeloid-derived suppressor cellsNeonatal sepsisSingle-cell RNA sequencingTrained immunity

Identifiers

PMID40307728
PMCPMC12042443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.