Evidence mapPaperPMID 40307757Full record

ArticleBMC gastroenterology2025

Gender difference in the association between serum uric acid and metabolic dysfunction-associated steatotic liver disease in patients with newly diagnosed type 2 diabetes.

Yuliang Cui, Zhenzhen Qu, Lingling Li, Wenmei Hu

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Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yuliang CuiDepartment of Endocrinology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, 253000, China.
Zhenzhen QuDepartment of Endocrinology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, 253000, China.
Lingling LiDepartment of Health Management, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, 253000, China.
Wenmei HuDepartment of Endocrinology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, 253000, China. dzhuwenmei@163.com.

Funding

Natural Science Foundation of Shandong Province ZR2021QH181
6 · The paper itself

Abstract

purposeTo investigate the relationship between serum uric acid (SUA) levels and metabolic dysfunction-associated steatotic liver disease (MASLD) in newly diagnosed type 2 diabetic patients.

methodsWe performed this retrospective research among 1087 inpatients with new-onset type 2 diabetes millitus (T2DM). Data were analyzed according to gender. Then, the populations were stratified according to their body mass index (BMI) levels in men and women, respectively. The physical and biochemical indicators were measured and recorded. The relationship between SUA and MASLD was estimated using logistic regression analysis, and the unadjusted and adjusted odds ratios (ORs) were calculated.

resultsAfter adjusting for age, BMI, and other components of the metabolic syndrome, SUA was independently associated with MASLD only in men, but not in women. In addition, for men, the SUA levels were independently associated with MASLD in both non-overweight/obesity and overweight/obesity group. However, for women, the SUA levels were independently related to MASLD in non-overweight/obesity group. There was no association between SUA and MASLD in women with overweight/obesity.

conclusionIn newly diagnosed type 2 diabetic patients, elevated SUA is an independent predictor for the risk of MASLD in males. In females, the relationship between SUA and MASLD may depend on BMI, with significance only in non-overweight/obese individuals.

Indexed as

Diabetes Mellitus, Type 2Fatty LiverMetabolic SyndromeUric AcidAdultAgedBody Mass IndexFemaleHumansLogistic ModelsMaleMiddle AgedObesityOverweightRetrospective StudiesRisk FactorsUric AcidMASLDSerum uric acidSexType 2 diabetes

Identifiers

PMID40307757
PMCPMC12042553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.