Evidence map›Paper›PMID 40308017›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2025

Pain Lateralization in Cluster Headache and Associated Clinical Factors.

Soohyun Cho, Mi Ji Lee, Min Kyung Chu, Jeong Wook Park, Heui-Soo Moon, Pil-Wook Chung, Jong-Hee Sohn, Byung-Su Kim, Daeyoung Kim, Kyungmi Oh and 2 more

Abstract read
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Does Laterality Matter? Insights Into Unilateral Pain in Cluster Headache.Journal of clinical neurology (Seoul, Korea) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Soohyun ChoDepartment of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea.ORCID https://orcid.org/0000-0002-3900-3204
Mi Ji LeeDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1364-1969
Min Kyung ChuDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6221-1346
Jeong Wook ParkDepartment of Neurology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea.ORCID https://orcid.org/0000-0001-5360-2951
Heui-Soo MoonDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6847-497X
Pil-Wook ChungDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8726-4812
Jong-Hee SohnDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-2656-9222
Byung-Su KimDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4014-9400
Daeyoung KimDepartment of Neurology, Chungnam National University College of Medicine, Daejeon, Korea.ORCID https://orcid.org/0000-0001-9056-0017
Kyungmi OhDepartment of Neurology, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7304-0308
Byung-Kun KimDepartment of Neurology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea. kbk1403@eulji.ac.kr.ORCID https://orcid.org/0000-0003-1053-4682
Soo-Jin ChoDepartment of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea. dowonc@naver.com.ORCID https://orcid.org/0000-0002-4053-3763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe pain lateralization in cluster headache (CH) may be related to the asymmetry in the functions of the brain hemispheres. The right-sided dominance of pain in CH has been found inconsistently across studies, and so we aimed to characterize this and identify the factors influencing pain lateralization during current and previous bouts.

methodsThis study enrolled 227 patients from the Korean Cluster Headache Registry between October 2018 and December 2020. We evaluated the side of pain during current and previous bouts, demographic features, and clinical characteristics, including handedness. Multivariable logistic regression analyses were performed to identify factors associated with the side of pain.

resultsThe 227 patients with CH included 131 (57.7%) with right-sided pain and 86 (37.9%) with left-sided pain during the current bout (

conclusionsThis study has confirmed the predominance of right-sided pain throughout multiple CH bouts. We found that higher age at diagnosis and shorter CH attacks were associated with left-side-locked pain, suggesting that certain clinical factors are associated with the pain laterality. However, the underlying mechanisms linking these factors to lateralized pain remain unclear and therefore require further investigation.

Indexed as

cluster headachehandednesslateralityside-locked pain

Identifiers

PMID40308017
PMCPMC12056138

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.