Evidence map›Paper›PMID 40308772›Full record

ArticleFrontiers in pharmacology2025

Repurposing major metabolites of lamiaceae family as potential inhibitors of

Soham Bhattacharya, Neha Gupta, Adrish Dutta, Pijush Kanti Khanra, Ritesh Dutta, Jana Žiarovská, Nikolay T Tzvetkov, Lucie Severová, Lenka Kopecká, Luigi Milella and 1 more

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In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Soham BhattacharyaDepartment of Agroecology and Crop Production, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czechia.
Neha GuptaDepartment of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Prague, Czechia.
Adrish DuttaDepartment of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Prague, Czechia.
Pijush Kanti KhanraDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Ritesh DuttaEnvironmental Biotechnology and Genomics Division, CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nagpur, India.
Jana ŽiarovskáInstitute of Plant and Environmental Sciences, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture in Nitra, Nitra, Slovakia.
Nikolay T TzvetkovDepartment of Biochemical Pharmacology and Drug Design, Institute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences (BAS), Sofia, Bulgaria.
Lucie SeverováDepartment of Economic Theories, Faculty of Economics and Management, Czech University of Life Sciences Prague, Prague, Czechia.
Lenka KopeckáDepartment of Economic Theories, Faculty of Economics and Management, Czech University of Life Sciences Prague, Prague, Czechia.
Luigi MilellaDepartment of Science, University of Basilicata, Potenza, Italy.
Eloy Fernández-CusimamaniDepartment of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders (NDs) are typically characterized by progressive loss of neuronal function and the deposition of misfolded proteins in the brain and peripheral organs. They are molecularly classified based on the specific proteins involved, underscoring the critical role of protein-processing systems in their pathogenesis. Alpha-synuclein (α-syn) is a neural protein that is crucial in initiating and progressing various NDs by directly or indirectly regulating other ND-associated proteins. Therefore, reducing the α-syn aggregation can be an excellent option for combating ND initiation and progression. This study presents an

Indexed as

functional network analysisMD simulationmolecular dockingneuroprotective agentpathway enrichment analysisphytochemical

Identifiers

PMID40308772
PMCPMC12041775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.